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RNA\u2010thiophosphoramidite monomers are commercially available from AM Biotechnologies and this unit describes an effective methodology for solid\u2010phase synthesis, deprotection, and purification of RNAs having PS2 internucleotide linkages. \u00a9 2017 by John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/cpnc.40","type":"journal-article","created":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T13:28:59Z","timestamp":1505741339000},"source":"Crossref","is-referenced-by-count":7,"title":["Solid\u2010Phase Synthesis of RNA Analogs Containing Phosphorodithioate Linkages"],"prefix":"10.1002","volume":"70","author":[{"given":"Xianbin","family":"Yang","sequence":"first","affiliation":[{"name":"AM Biotechnologies, Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,13]]},"reference":[{"key":"e_1_2_5_2_1_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw725"},{"key":"e_1_2_5_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2006.01.001"},{"key":"e_1_2_5_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2005.06.011"},{"key":"e_1_2_5_2_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.010909.105547"},{"key":"e_1_2_5_2_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp106"},{"key":"e_1_2_5_2_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2012.07.011"},{"key":"e_1_2_5_2_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi000146a"},{"key":"e_1_2_5_2_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/35078107"},{"key":"e_1_2_5_2_9_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.82499\u20100"},{"key":"e_1_2_5_2_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.03.201"},{"key":"e_1_2_5_2_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471142727.mb1002as97"},{"key":"e_1_2_5_2_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0040\u20104039(96)00882\u20109"},{"key":"e_1_2_5_2_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac101106m"},{"key":"e_1_2_5_2_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359\u20106446(04)03050\u20108"},{"key":"e_1_2_5_2_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3141"},{"key":"e_1_2_5_2_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02172106"},{"key":"e_1_2_5_2_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo301834p"},{"key":"e_1_2_5_2_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7681216"},{"key":"e_1_2_5_2_19_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.10.6.15119"},{"key":"e_1_2_5_2_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr960009c"},{"key":"e_1_2_5_2_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4RA10986D"},{"key":"e_1_2_5_2_22_1","first-page":"224","article-title":"Nucleic acid aptamers for target validation and therapeutic applications","volume":"16","author":"Pendergrast P. 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