{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:57:58Z","timestamp":1792015078186,"version":"4.4.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T00:00:00Z","timestamp":1556841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["currentprotocols.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CP Neuroscience"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Haloperidol is a first\u2010generation antipsychotic used in the treatment of psychoses, especially schizophrenia. This drug acts by blocking dopamine D2 receptors, reducing psychotic symptoms. Notwithstanding its benefits, haloperidol also produces undesirable impacts, in particular extrapyramidal effects such as tardive dyskinesia (TD), which limit the use of this and related drugs. TD is characterized by repetitive involuntary movements occurring after chronic exposure therapy with haloperidol. Symptoms most commonly manifest in the orofacial area and include involuntary movements, tongue protrusion, pouting lips, chewing in the absence of any object to chew, and facial grimacing. The most serious aspect of TD is that it may persist for months or years after drug withdrawal and is irreversible in some patients. This unit, aimed at facilitating the study of TD, describes methods to induce TD in rats using haloperidol, as well as procedures for evaluating the animals's TD\u2010related symptoms. \u00a9 2019 by John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/cpns.68","type":"journal-article","created":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T13:56:53Z","timestamp":1556891813000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Haloperidol\u2010Induced Preclinical Tardive Dyskinesia Model in Rats"],"prefix":"10.1002","volume":"88","author":[{"given":"Fausto Pierdon\u00e1","family":"Guzen","sequence":"first","affiliation":[{"name":"Faculty of Medicine State University of Rio Grande do Norte (UERN)  Mossor\u00f3 Rio Grande do Norte Brazil"},{"name":"Potiguar University, Laureate International Universities  Mossor\u00f3 Rio Grande do Norte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Rodolfo Lopes de Paiva","family":"Cavalcanti","sequence":"additional","affiliation":[{"name":"Faculty of Medicine State University of Rio Grande do Norte (UERN)  Mossor\u00f3 Rio Grande do Norte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo Manuel Lopes de Paiva","family":"Cavalcanti","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Federal Rural University of Semi\u2010Arid (UFERSA)  Mossor\u00f3 Rio Grande do Norte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luma Gabrielle Praxedes","family":"de Sales","sequence":"additional","affiliation":[{"name":"Faculty of Nursing State University of Rio Grande do Norte (UERN)  Mossor\u00f3 Rio Grande do Norte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monalisa Stefany Martins","family":"da Silva","sequence":"additional","affiliation":[{"name":"Faculty of Nursing State University of Rio Grande do Norte (UERN)  Mossor\u00f3 Rio Grande do Norte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline Naiara Azevedo","family":"da Silva","sequence":"additional","affiliation":[{"name":"Faculty of Medicine State University of Rio Grande do Norte (UERN)  Mossor\u00f3 Rio Grande do Norte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Irochima","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Potiguar University, Laureate International Universities  Mossor\u00f3 Rio Grande do Norte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayane Pessoa","family":"de Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Faculty of Nursing State University of Rio Grande do Norte (UERN)  Mossor\u00f3 Rio Grande do Norte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00160-2"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2016-0307"},{"key":"e_1_2_10_4_1","first-page":"74","article-title":"Neuroleptic side effects: Acute extrapyramidal syndromes and tardive dyskinesia","volume":"5","author":"Casey D. E.","year":"1988","journal-title":"Psychopharmacology Series"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2011.07.014"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0104-42302010000100024"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050095"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02245692"},{"key":"e_1_2_10_9_1","unstructured":"Grassl C.(2004).Possible participation of the sex factor in an animal model of tardive dyskinesia. (research notes published) Universidade Federal de S\u00e3o Paulo (UNIFESP) S\u00e3o Paulo: 2004."},{"key":"e_1_2_10_10_1","first-page":"268","article-title":"Persistent spontaneous oral dyskinesias in haloperidol\u2010withdrawn rats neonatally lesioned with 6\u2010hydroxydopamine\u2014absence of an association with the B\n                  max for [3H]raclopride binding to neostriatal homolog","volume":"280","author":"Huang N. Y.","year":"1997","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/19.2.303"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(02)01051-1"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-012-9345-3"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(97)00394-9"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00427326"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(76)90119-9"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(90)90077-J"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(02)00008-8"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5846(98)00032-3"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.155.4.565"}],"container-title":["Current Protocols in Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpns.68","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cpns.68","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/currentprotocols.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpns.68","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T22:17:34Z","timestamp":1694384254000},"score":1,"resource":{"primary":{"URL":"https:\/\/currentprotocols.onlinelibrary.wiley.com\/doi\/10.1002\/cpns.68"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,3]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1002\/cpns.68"],"URL":"https:\/\/doi.org\/10.1002\/cpns.68","archive":["Portico"],"relation":{},"ISSN":["1934-8584","1934-8576"],"issn-type":[{"value":"1934-8584","type":"print"},{"value":"1934-8576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,3]]},"assertion":[{"value":"2019-05-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e68"}}