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Incentive sensitivity in bipolar disorder seems to be related to two processes: a tendency to invest in difficult\u2010to\u2010attain goals and an over\u2010reactivity to cues of goal progress versus thwarting. Both of those processes appear relevant to symptom generation. Hence, bipolar disorder seems related to a greater emphasis on reaching goals and also a problematic reactivity to reaching those highly desired goals. We suggest directions for treatment development focused on these issues in goal regulation. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p><jats:sec><jats:title>Key Practitioner Message<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>For people with bipolar disorder, heightened approach motivation appears to be manifested in setting extremely high goals, expending extraordinary resources towards those goals and reacting in more prolonged ways to goal progress or thwarting.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Early prodromal signs of mania may involve increased goal pursuit and heightened activity.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Each of these facets could potentially be amenable to cognitive behavioural intervention.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p><\/jats:sec><\/jats:sec>","DOI":"10.1002\/cpp.1801","type":"journal-article","created":{"date-parts":[[2012,5,21]],"date-time":"2012-05-21T09:06:23Z","timestamp":1337591183000},"page":"352-362","source":"Crossref","is-referenced-by-count":47,"title":["The Double\u2010Edged Sword of Goal Engagement: Consequences of Goal Pursuit in Bipolar Disorder"],"prefix":"10.1002","volume":"19","author":[{"given":"Sheri L.","family":"Johnson","sequence":"first","affiliation":[{"name":"University of California  Berkley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Fulford","sequence":"additional","affiliation":[{"name":"University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles S.","family":"Carver","sequence":"additional","affiliation":[{"name":"University of Miami  Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,21]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v66n0715"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0963721410370292"},{"key":"e_1_2_16_4_1","unstructured":"Alloy L.B. 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