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Complementary interventions, such as psychosocial and psychoeducational treatments, can help children and their families manage mood regulation and other challenges throughout childhood and adolescence. However, most research on such interventions has focused on children, single\u2010family psychoeducation, and individual cognitive behavioural therapy. The present study, conducted in Sweden, used a case\u2010series design to explore whether child\u2010 and family\u2010focused cognitive behavioural therapy (CFF\u2010CBT) for PBD, adapted from children (8\u201312 years) to adolescents (13\u201318 years) and applied in a multi\u2010family format, could help reduce symptoms, improve psychosocial functioning, increase parents' knowledge of and skills for coping with the disorder, and improve family expressed emotion for adolescents with PBD. Furthermore, we aimed to assess whether the effects of such CFF\u2010CBT are maintained at a one\u2010year follow\u2010up. Seven adolescents and 11 parents in two multi\u2010family groups received twelve sessions of CFF\u2010CBT. Self\u2010rating questionnaires and clinical observations were used to evaluate clinically significant changes for individual cases. The results suggest that CFF\u2010CBT is feasible to deliver in an outpatient psychiatric setting and may be effective for developing parents' skills and knowledge for coping with PBD, increasing adolescents' psychosocial functioning, and improving family climate. The results are in line with previous findings on CFF\u2010CBT for children with PBD, suggesting that CFF\u2010CBT is a valuable adjunctive treatment for adolescents with PBD. Copyright \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Practitioner Message<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Preliminary evidence indicates that CFF\u2010CBT (RAINBOW) is both acceptable and an important complement to pharmacological treatment for adolescents suffering from paediatric bipolar disorder (PBD).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Adolescent PBD populations show a high degree of comorbidity and individual clinical presentations that influence treatment results.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Families show a large variation in ability to participate and benefit from RAINBOW treatment. Assessing and addressing pre\u2010treatment environmental stressors and family climate during treatment is important for optimizing treatment effect.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Symptoms of PBD fluctuate and new episodes can occur spontaneously. It is therefore important to follow PBD symptoms over time to draw more precise conclusions on treatment effects.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>When assessing treatment effects on psychiatric symptoms, social functioning, and family climate, it is important to use multiple rating sources, as ratings can vary considerably between adolescents, parents, and clinicians.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/cpp.2027","type":"journal-article","created":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T07:25:19Z","timestamp":1466061919000},"page":"589-617","source":"Crossref","is-referenced-by-count":11,"title":["Adolescent and Family\u2010focused Cognitive\u2013behavioural Therapy for Paediatric Bipolar Disorders: A Case Series"],"prefix":"10.1002","volume":"24","author":[{"given":"Jens","family":"Knutsson","sequence":"first","affiliation":[{"name":"Department of Psychology Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beata","family":"B\u00e4ckstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Psychoses and Bipolar Disorders Clinic for Child and Adolescent Psychiatry  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiva","family":"Daukantait\u0117","sequence":"additional","affiliation":[{"name":"Department of Psychology Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fredrik","family":"Lecerof","sequence":"additional","affiliation":[{"name":"Department of Psychoses and Bipolar Disorders Clinic for Child and Adolescent Psychiatry  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.04.022"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1987.01800210069011"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/camh.12021"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2009.08101569"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.11.006"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2009.06.037"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1037\/0003-066x.63.2.77"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-859X-10-18"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2007.01108.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.55.6.547"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.2051-5545.2012.tb00115.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.2.213"},{"key":"e_1_2_6_14_1","first-page":"3","article-title":"Update on empirically validated therapies II","volume":"51","author":"Chambless D. 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