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One unanswered question is whether meaning\u2010making is a mediator of the change in anxiety and depression symptoms in participants with adjustment disorders during cognitive behavioural therapy (CBT) treatment. The aims of this study were (a) to analyse whether there was meaning\u2010making during the application of the CBT, (b) to analyse whether meaning\u2010making was a mediator of anxiety psychopathology and (c) to analyse whether meaning\u2010making was a mediator of depressive symptoms. The sample was composed of 115 patients who satisfied the full Diagnostic and Statistical Manual of Mental Disorders (DSM)\u20105 criteria for adjustment disorder as their primary diagnosis and completed CBT treatment in a primary care mental health service: 74.78% women, <jats:italic>n<\/jats:italic> = 86, and 25.22% men, <jats:italic>n<\/jats:italic> = 29, with a mean age of 41.89 (standard deviation [<jats:italic>SD<\/jats:italic>] = 10.39) years. The diagnosis was established using the Structured Clinical Interview for DSM\u20105 (SCID\u20105), and participants filled out the Beck Anxiety Inventory, the Beck Depression Inventory and Purpose in Life questionnaires. The therapists were clinical psychologists with experience in clinical assessment. A repeated\u2010measures analysis of variance (ANOVA) and two mediation analyses using the bootstrap method were performed. The results indicated that (a) There was meaning\u2010making during the CBT because the treated sample showed a statistically significant improvement in meaning in life, and (b) meaning\u2010making during the CBT was a partial mediator between anxiety symptoms and depressive symptoms before and after the treatment. The present study suggests that meaning in life could be an important variable in the psychopathology of adjustment disorders.<\/jats:p>","DOI":"10.1002\/cpp.2506","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T14:45:58Z","timestamp":1599144358000},"page":"325-333","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Meaning\u2010making as a mediator of anxiety and depression reduction during cognitive behavioral therapy intervention in participants with adjustment disorders"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1545-6452","authenticated-orcid":false,"given":"Jos\u00e9 H.","family":"Marco","sequence":"first","affiliation":[{"name":"Departamento de Personalidad, Evaluaci\u00f3n y Tratamientos Psicol\u00f3gicos Universitat de Val\u00e8ncia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Alonso","sequence":"additional","affiliation":[{"name":"Catedra UMIVALE Innovaci\u00f3n e Investigaci\u00f3n en la Patologia del Trabajo  Valencia Spain"},{"name":"Escuela de Doctorado Universidad Cat\u00f3lica de Valencia, San Vicente M\u00e1rtir  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Ba\u00f1os","sequence":"additional","affiliation":[{"name":"Departamento de Personalidad, Evaluaci\u00f3n y Tratamientos Psicol\u00f3gicos Universitat de Val\u00e8ncia  Valencia Spain"},{"name":"Ciber Fisiopatologia Obesidad y Nutrici\u00f3n (CB06\/03) Instituto Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.64.6.1417"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_6_4_1","volume-title":"Manual for the Beck Anxiety Inventory","author":"Beck A. 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