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The current study aims to present a comprehensive evaluation of the literature examining the relationship between the exposure to childhood adversities, repetitive negative thinking and clinical outcomes in adulthood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In accordance with Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses (PRISMA) criteria, a search was conducted on PubMed and Ebsco. A manual search of reference lists was also run. Search terms were \u2018childhood adversity\/childhood abuse\/childhood neglect\/early loss event AND worry or rumination\u2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 18 studies met the inclusion criteria. In both non\u2010clinical and clinical populations, worry and rumination seem to be common among adults exposed to childhood abuse or childhood neglect. Among adults who have been exposed to childhood adversities, rumination seems to be associated with worse clinical outcomes such as severe psychiatric symptoms, depression, dysphoria, suicidal ideation, cognitive complaints, post\u2010traumatic stress symptoms and aggression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Early experiences of abuse and neglect may be associated with a tendency to engage in repetitive negative thinking, such as worry and rumination, in adulthood. Among adults, with a history of childhood adversities, tailored treatment to reduce repetitive negative thinking should be considered.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cpp.2590","type":"journal-article","created":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T00:46:20Z","timestamp":1618620380000},"page":"557-568","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":108,"title":["Adverse childhood experiences and repetitive negative thinking in adulthood: A systematic review"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9571-2486","authenticated-orcid":false,"given":"Giovanni","family":"Mansueto","sequence":"first","affiliation":[{"name":"Department of Psychology Sigmund Freud University  Milan Italy"},{"name":"Department of Health Sciences University of Florence  Florence 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