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However, there is a need to go beyond simple associations and identify candidate mechanisms underpinning the ACEs\u2013mental health relationship. Further methodological heterogeneity points to issues around the operationalization of ACEs and the importance of modelling data using robust research designs. The aim of the current review was to synthesize studies that utilized formal mediation and\/or moderation analyses to explore psychological and social variables on the pathway between clearly defined ACEs (as measured by the ACE questionnaire and Childhood Trauma Questionnaire [CTQ]) and common mental health outcomes (depressive, anxiety and post\u2010traumatic stress disorder [PTSD] symptoms) across community samples aged over 18. A total of 31 papers were retrieved for critical appraisal. The majority of the studies explored factors mediating\/moderating the link between child adversity and depression and less on anxiety and trauma. Most mechanisms were tested in only single studies, limiting the consistency of evidence. Evidence indicated that the mechanisms underlying associations between ACEs and adult mental health are likely to reflect multiple intervening variables. Further, there are substantial methodological limitations in the extant literature including the proliferation of causal inferences from cross\u2010sectional designs and both measurement and conceptual issues in operationalizing adversity. Consistent transdiagnostic mechanisms relevant to common mental health problems were identified, including perceived social support, emotion regulation and negative cognitive appraisals\/beliefs. Further research using longitudinal design is required to delineate the potential contribution of the identified mechanisms.<\/jats:p>","DOI":"10.1002\/cpp.2732","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T12:54:26Z","timestamp":1646916866000},"page":"1626-1654","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Deconstructing pathways to resilience: A systematic review of associations between psychosocial mechanisms and transdiagnostic adult mental health outcomes in the context of adverse childhood experiences"],"prefix":"10.1002","volume":"29","author":[{"given":"Corinna","family":"Panagou","sequence":"first","affiliation":[{"name":"School of Health in Social Science University of Edinburgh  Edinburgh EH8 9AG UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0618-044X","authenticated-orcid":false,"given":"Angus","family":"MacBeth","sequence":"additional","affiliation":[{"name":"School of Health in Social Science University of Edinburgh  Edinburgh EH8 9AG UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579419001317"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2017.01984"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbaa030.428"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.113.131227"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2019.0097"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-6748.77642"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1077559517736628"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.51.6.1173"},{"key":"e_1_2_8_10_1","volume-title":"Beck Depression Inventory (BDI\u2010II)","author":"Beck A. 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