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In particular, the development of mental illness and\/or psychological symptomatology in this population was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This qualitative systematic review looked at interventions targeting children aged 4\u201318\u2009years without a diagnosed mental disorder, alone or with their families, with a parent with a diagnosed mental disorder. The protocol was pre\u2010registered in Open Science Framework. A total of 1255 references were retrieved from MEDLINE, PsychArticles, PsycINFO, Springer Link, Science Direct, Scopus and WOS databases, and 12 references from grey literature. This search was replicated by an external reviewer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen studies involving 1941 children and 1328 parents were included. Interventions were based on cognitive\u2010behavioural and\/or psychoeducational components, including six randomized controlled trials. Internalizing symptomatology was assessed in 80% of the studies, externalizing and prosocial behaviour in 47%, and coping style in 33%. Only two studies measured the future risk of developing a mental disorder (ORs of 2.37 and 6.6). There was variability in the format of the intervention (group; family) as well as in the type of intervention and its duration (from one session to 12 sessions).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Interventions for children of parents with mental disorder were clinically and statistically significant, especially in preventing internalizing symptomatology at one\u2010year follow\u2010up, with effect sizes ranging from <jats:italic>d<\/jats:italic>\u2009=\u2009\u22120.28 to 0.57 (95% CI).<\/jats:p><\/jats:sec>","DOI":"10.1002\/cpp.2850","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T23:33:07Z","timestamp":1680219187000},"page":"979-997","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Preventive interventions for children and adolescents of parents with mental illness: A systematic review"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7953-9273","authenticated-orcid":false,"given":"Itzal","family":"Puchol\u2010Mart\u00ednez","sequence":"first","affiliation":[{"name":"Escuela Internacional de Doctorado, Institute of Public and Occupational Health of Navarre Universidad Nacional de Educaci\u00f3n a Distancia (UNED)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d3scar","family":"Vallina F\u00e9rnandez","sequence":"additional","affiliation":[{"name":"Hospital Sierrallana\u2010Tres Mares, Servicio C\u00e1ntabro de Salud  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Santed\u2010Germ\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Personality Evaluation and Psychological Treatment Universidad Nacional de Educaci\u00f3n a Distancia (UNED)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-859X-10-2"},{"key":"e_1_2_11_3_1","volume-title":"Parenting stress index: Professional manual","author":"Abidin R. 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