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While documented evidence links NSSI to childhood trauma, depression, social support, a comprehensive perspective that integrates these factors together is lacking. To bridge this gap, we leveraged a chain\u2010mediating model in this study, to examine the mediating effect of social support and depression on the relationship between childhood trauma and NSSI. As expected, NSSI behaviours were positively correlated with depression scores (<jats:italic>r<\/jats:italic>\u2009=\u20090.492, <jats:italic>p<\/jats:italic><jats:sub>adj<\/jats:sub>\u2009&lt;\u20090.001), childhood trauma scores (<jats:italic>r<\/jats:italic>\u2009=\u20090.306, <jats:italic>p<\/jats:italic><jats:sub>adj<\/jats:sub>\u2009&lt;\u20090.001), and negatively correlated with the social support scores (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.168, <jats:italic>p<\/jats:italic><jats:sub>adj<\/jats:sub>\u2009=\u20090.020). Importantly, in the chain\u2010mediating model, increased childhood trauma was associated with decreased social support (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.532, <jats:italic>t<\/jats:italic>\u2009=\u2009\u22129.086, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), which in turn was linked with increased depressive symptoms (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.193, <jats:italic>t<\/jats:italic>\u2009=\u2009\u22122.957, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), ultimately contributing to greater odds of NSSI behaviours. Our findings elucidated the complex psychological mechanisms underlying the interplay between childhood trauma, social support and depression severity, suggesting that improving social support and intervening early in depression may be potential ways to reduce the risk of NSSI.<\/jats:p>","DOI":"10.1002\/cpp.70030","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T14:09:42Z","timestamp":1737986982000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Social Support and Depression Mediate the Relationship Between Childhood Trauma and Nonsuicidal Self\u2010Injury"],"prefix":"10.1002","volume":"32","author":[{"given":"Jiazheng","family":"Yao","sequence":"first","affiliation":[{"name":"School of Health Management Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurong","family":"Zou","sequence":"additional","affiliation":[{"name":"School of Health Management Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianyi","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology, the Affiliated Brain Hospital Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Health Management Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tse","family":"Chunghon","sequence":"additional","affiliation":[{"name":"Sales Department China State Construction INT'L Medical Industry Development (Shenzhen), Co. 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