{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T13:04:29Z","timestamp":1788354269246,"version":"build-2803163510"},"reference-count":64,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"vor","delay-in-days":53,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Psychology and Psychoth"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Functional disorders (FDs) benefit from psychotherapy. However, the determinants predicting their efficacy remain largely unexplored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic literature review was conducted. PubMed, Web of Science, Embase, Cochrane collaboration and grey literature were screened from inception to November 2024. Randomized controlled trials on predictors of success of psychotherapy for FDs (e.g., somatoform disorders, irritable bowel syndrome [IBS], chronic fatigue syndrome\/myalgic encephalomyelitis [CFS\/ME], fibromyalgia [FM]) in adults (i.e., \u2265\u200918\u2009years of age) were included. The review yielded 24 eligible studies and included 3382 participants. A standardized quality assessment via ROB\u20102 Tool was performed. PRISMA guidelines were followed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most studies applied CBT\u2010based interventions (<jats:italic>n<\/jats:italic>\u2009=\u200919), mainly face\u2010to\u2010face, with some internet\u2010based (<jats:italic>n<\/jats:italic>\u2009=\u20095), while fewer used emotional\u2010based (<jats:italic>n<\/jats:italic>\u2009=\u20094), mindfulness\u2010based (<jats:italic>n<\/jats:italic>\u2009=\u20093), psychodynamic (<jats:italic>n<\/jats:italic>\u2009=\u20091) or operant behavioural therapy (<jats:italic>n<\/jats:italic>\u2009=\u20091). The primary factors identified as predictive of treatment success in FM and somatization were the intensity of experienced pain. Moreover, the presence of mental disorders, i.e., depression and anxiety disorders, emerged as predictors for a range of disorders including FM, IBS, somatization disorder, hypochondriasis, medically unexplained symptoms and dissociative seizures. Symptom severity was recognized as a predictor across various FDs with findings indicated that severe severity could predict treatment outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The body of research concerning predictors of treatment success in the context of FDs can help clinicians identifying appropriate psychotherapy trajectories.<\/jats:p><jats:p><jats:bold>Trial Registration:<\/jats:bold> Not applicable. PROSPERO no. CRD42022379791; OSF (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/osf.io\/8q7z9\">https:\/\/osf.io\/8q7z9<\/jats:ext-link>).<\/jats:p><\/jats:sec>","DOI":"10.1002\/cpp.70075","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:49:48Z","timestamp":1745444988000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Predictors of Treatment Success of Psychotherapy in Functional Disorders: A Systematic Review of the Literature"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3172-0823","authenticated-orcid":false,"given":"Caroline","family":"Rometsch","sequence":"first","affiliation":[{"name":"Department of Experimental and Clinical Medicine University of Florence  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4235-8591","authenticated-orcid":false,"given":"Alexandra","family":"Martin","sequence":"additional","affiliation":[{"name":"School of Human and Social Sciences University of Wuppertal  Wuppertal Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5022-0488","authenticated-orcid":false,"given":"Fiammetta","family":"Cosci","sequence":"additional","affiliation":[{"name":"Department of Health Sciences University of Florence  Italy"},{"name":"Department of Psychiatry and Neuropsychology Maastricht University  Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2021.110473"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2019.02.030"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2020.0940"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2019.102172"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2005.01.003"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-020-1505-4"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.encep.2023.06.004"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3122\/jabfm.2022.220335R1"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/fmch-2019-000262"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2023.111175"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.184.6.470"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-116-12-1009"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.847460"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000448856"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000288931"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000507793"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.148"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-18539-2"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000802"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2021.628977"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2013.07.011"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2022.110921"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90215-7"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(94)90026-4"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24276"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2013.07.009"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000315130"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1037\/ccp0000483"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjpain.2015.04.027"},{"issue":"11","key":"e_1_2_12_32_1","article-title":"Pharmacological Interventions for Somatoform Disorders in Adults","volume":"2014","author":"Kleinstaeuber M.","year":"2014","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00646"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2004.02.012"},{"key":"e_1_2_12_35_1","article-title":"Healthcare\u2010Related Factors Influencing Symptom Persistence, Deterioration, or Improvement in Patients With Persistent Somatic Symptoms: A Scoping Review of European Studies","volume":"111485","author":"Kustra\u2010Mulder A.","year":"2023","journal-title":"Journal of Psychosomatic Research"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.02.007"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000200111"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.08.073"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.10.114"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-11-110"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00623-8"},{"key":"e_1_2_12_42_1","article-title":"Characteristics of Collaborative Care Networks in Functional Disorders: A Systematic Review","volume":"111357","author":"Mamo N.","year":"2023","journal-title":"Journal of Psychosomatic Research"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2022.111068"},{"key":"e_1_2_12_44_1","first-page":"1","article-title":"Predictors of Response to Cognitive Behavioural Therapy (CBT) for Individuals With Obsessive\u2010Compulsive Disorder (OCD): A Systematic Review","author":"McDonald S.","year":"2023","journal-title":"Behavioural and Cognitive Psychotherapy"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biosystems.2017.12.010"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-014-0579-0"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1159\/000320122"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-016-0384-4"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2021.105906"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04198-2"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/jclp.22356"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-024-01109-5"},{"issue":"2","key":"e_1_2_12_53_1","first-page":"142","article-title":"The European Training Network ETUDE (Encompassing Training in Functional Disorders Across Europe) Is Recruiting 15 Early\u2010Stage Researchers","volume":"90","author":"Rosmalen J.","year":"2021","journal-title":"Psychotherapy and Psychosomatics"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2020.110345"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291721003871"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2022.03.001"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2023.111155"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2022.08.041"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22778"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0020052"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2015.06.006"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1159\/000348588"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2015.05.008"},{"key":"e_1_2_12_64_1","volume-title":"The ICD\u201010 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines","author":"World Health Organization","year":"1992"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-12-848"}],"container-title":["Clinical Psychology &amp; Psychotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpp.70075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T13:10:25Z","timestamp":1753708225000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cpp.70075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":64,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/cpp.70075"],"URL":"https:\/\/doi.org\/10.1002\/cpp.70075","archive":["Portico"],"relation":{},"ISSN":["1063-3995","1099-0879"],"issn-type":[{"value":"1063-3995","type":"print"},{"value":"1099-0879","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2025-02-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70075"}}