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This study examined a manualised, temperament\u2010informed schema therapy protocol (ST\u2010BED\u2010TI) targeting early maladaptive schemas (EMS), schema modes and interoception in adults with complex BED. A prospective case series was conducted with five adult women with long\u2010standing BED and high clinical complexity, who received between 25 and 35 sessions of ST\u2010BED\u2010TI in outpatient services in Australia and the United Kingdom. Individual change was evaluated with reliable change indices and clinical significance for global eating disorder (ED) symptom scores. This trial was pre\u2010registered on the Australian New Zealand Clinical Trials Register (ID: ACTRN12623001259639). Four of five participants showed reliable and clinically significant improvement in global ED symptoms at post\u2010treatment; three of the four measured at 6\u2010month follow\u2010up maintained these gains. All participants reported reductions in binge eating frequency. Most demonstrated reliable improvements in key EMS, schema modes and at least one interoceptive awareness domain, with one case showing marked interoceptive gains despite limited measurable EMS or mode change. Within the limits of a small uncontrolled case series, ST\u2010BED\u2010TI appears acceptable, clinically manageable and promising in this pilot context. These preliminary findings warrant larger controlled and mechanism\u2010focused studies.<\/jats:p>","DOI":"10.1002\/cpp.70348","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:30:13Z","timestamp":1790857813000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Addressing Schemas, Modes and Interoceptive Disconnection in Chronic Binge Eating Disorder: A Temperament\u2010Informed Schema Therapy Case Series"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1526-600X","authenticated-orcid":false,"given":"Phoebe R.","family":"Joshua","sequence":"first","affiliation":[{"name":"Discipline of Psychology, Faculty of Health University of Canberra  Canberra Australian Capital Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Simpson","sequence":"additional","affiliation":[{"name":"NHS Forth Valley  Larbert UK"},{"name":"Adelaide University  Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9261-1276","authenticated-orcid":false,"given":"Vivienne","family":"Lewis","sequence":"additional","affiliation":[{"name":"Discipline of Psychology, Faculty of Health University of Canberra  Canberra Australian Capital Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9631-1740","authenticated-orcid":false,"given":"Sally F.","family":"Kelty","sequence":"additional","affiliation":[{"name":"Discipline of Psychology, Faculty of Health University of Canberra  Canberra Australian Capital Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpp.70153"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.2196\/74057"},{"key":"e_1_2_12_4_1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association.2022.Diagnostic and Statistical Manual of Mental Disorders Fifth Edition Text Revision (DSM\u20105\u2010TR).https:\/\/doi.org\/10.1176\/appi.books.9780890425787.","DOI":"10.1176\/appi.books.9780890425787"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00127\u2010022\u201002223\u2010z"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2019.e02361"},{"key":"e_1_2_12_7_1","doi-asserted-by":"crossref","DOI":"10.1017\/9781108918145","volume-title":"Cambridge Guide to Schema Therapy","author":"Brockman R. 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