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However, the systemic disease manifestation in NOD mice is sensitive to the housing environment, as stress modulates the immune system, so it is essential to confirm that readouts are robust, reproducible, and sensitive to known clinical treatments. This protocol describes the establishment of the spontaneous NOD model of SS and underscores the necessity of model validation to ensure that the housing environment is compatible. \u00a9 2019 by John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/cpph.65","type":"journal-article","created":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T12:03:54Z","timestamp":1565006634000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Spontaneous Model of Sj\u00f6gren's Syndrome in NOD Mice"],"prefix":"10.1002","volume":"86","author":[{"given":"Monika D.","family":"Scuron","sequence":"first","affiliation":[{"name":"Incyte Corporation  Wilmington Delaware"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany","family":"Fay","sequence":"additional","affiliation":[{"name":"Incyte Corporation  Wilmington Delaware"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Oliver","sequence":"additional","affiliation":[{"name":"Incyte Corporation  Wilmington Delaware"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Smith","sequence":"additional","affiliation":[{"name":"Incyte Corporation  Wilmington Delaware"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,5]]},"reference":[{"key":"e_1_2_7_2_1_1","volume-title":"Techniques training: Mouse, a visual guide to research techniques","author":"AALAS.","year":"2011"},{"key":"e_1_2_7_2_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.23.021704.115643"},{"key":"e_1_2_7_2_3_1","volume-title":"AVMA guidelines for the euthanasia of animals: 2013 edition","author":"AVMA Panel on Euthanasia.","year":"2013"},{"key":"e_1_2_7_2_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2016.217"},{"issue":"6","key":"e_1_2_7_2_5_1","first-page":"883","article-title":"Acclimatization of mice to different cage types and social groupings with respect to fecal secretion of IgA and corticosterone metabolites","volume":"26","author":"Bundgaard C. 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