{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:10:13Z","timestamp":1791519013531,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T00:00:00Z","timestamp":1517529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["1P50GM115305\u201001"],"award-info":[{"award-number":["1P50GM115305\u201001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["1R01AI103348\u201001"],"award-info":[{"award-number":["1R01AI103348\u201001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["1P30AI110527\u201001A1"],"award-info":[{"award-number":["1P30AI110527\u201001A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["5T32AI007474\u201020"],"award-info":[{"award-number":["5T32AI007474\u201020"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["1R13AR71267\u201001"],"award-info":[{"award-number":["1R13AR71267\u201001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>\n                    The variant allele\n                    <jats:italic>HLA\u2010B*15:02<\/jats:italic>\n                    is strongly associated with greater risk of Stevens\u2013Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in patients treated with carbamazepine or oxcarbazepine. The variant allele\n                    <jats:italic>HLA\u2010A*31:01<\/jats:italic>\n                    is associated with greater risk of maculopapular exanthema, drug reaction with eosinophilia and systemic symptoms, and SJS\/TEN in patients treated with carbamazepine. We summarize evidence from the published literature supporting these associations and provide recommendations for carbamazepine and oxcarbazepine use based on\n                    <jats:italic>HLA<\/jats:italic>\n                    genotypes.\n                  <\/jats:p>","DOI":"10.1002\/cpt.1004","type":"journal-article","created":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T04:12:47Z","timestamp":1517544767000},"page":"574-581","source":"Crossref","is-referenced-by-count":312,"title":["Clinical Pharmacogenetics Implementation Consortium Guideline for\n                    <i>HLA<\/i>\n                    Genotype and Use of Carbamazepine and Oxcarbazepine: 2017 Update"],"prefix":"10.1111","volume":"103","author":[{"given":"Elizabeth J.","family":"Phillips","sequence":"first","affiliation":[{"name":"Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chonlaphat","family":"Sukasem","sequence":"additional","affiliation":[{"name":"Division of Pharmacogenomics and Personalized Medicine, Department of Pathology Faculty of Medicine Ramathibodi Hospital, Mahidol University Bangkok Thailand"},{"name":"Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center Faculty of Medicine Ramathibodi Hospital Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Whirl\u2010Carrillo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data Science Stanford University Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health Toronto Ontario Canada"},{"name":"Department of Psychiatry and Pharmacology &amp; Toxicology University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry M.","family":"Dunnenberger","sequence":"additional","affiliation":[{"name":"Center for Molecular Medicine, NorthShore University HealthSystem Evanston Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wasun","family":"Chantratita","sequence":"additional","affiliation":[{"name":"Virology Laboratory, Department of Pathology Faculty of Medicine Ramathibodi Hospital, Mahidol University Bangkok Thailand"},{"name":"Center for Medical Genomics, Ramathibodi Hospital, Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Goldspiel","sequence":"additional","affiliation":[{"name":"Pharmacy Department National Institutes of Health Clinical Center Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan\u2010Tsong","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, Academia Sinica Taipei Taiwan"},{"name":"Department of Pediatrics Duke University Medical Center Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce C.","family":"Carleton","sequence":"additional","affiliation":[{"name":"Division of Translational Therapeutics, Department of Pediatrics Faculty of Medicine, University of British Columbia, and BC Children's Hospital Research Institute Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Alfred L.","family":"George","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Northwestern University Feinberg School of Medicine Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taisei","family":"Mushiroda","sequence":"additional","affiliation":[{"name":"Laboratory for Pharmacogenomics, RIKEN Center for Integrative Medical Science Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teri","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data Science Stanford University Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roseann S.","family":"Gammal","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice MCPHS University Boston Massachusetts USA"},{"name":"Department of Pharmaceutical Sciences St. Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munir","family":"Pirmohamed","sequence":"additional","affiliation":[{"name":"Department of Pharmacology University of Liverpool Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,2]]},"reference":[{"key":"e_1_2_11_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2013.103"},{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2011.355"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30681"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.5935\/0103-507X.20130049"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01334-14"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2014.159"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2014.38"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.161"},{"key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0022-3565(25)24848-0","article-title":"Carbamazepine and 10,11\u2010epoxycarbamazepine produce use\u2010 and voltage\u2010dependent limitation of rapidly firing action potentials of mouse central neurons in cell culture","volume":"238","author":"McLean M.J.","year":"1986","journal-title":"J. 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