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We performed a meta\u2010analysis including randomized, placebo\u2010controlled trials reporting cough on ACE\u2010I in patients with CVD. We evaluated the attributable fraction of cough on ACE\u2010I accounting rate on placebo: placebo\u2010adjusted ACE\u2010I (%)\u2009=\u2009(ACE\u2010I (%) \u2013 Placebo (%)) \/ ACE\u2010I (%). In total, 65,054 patients from 22 included studies were analyzed. Placebo\u2010adjusted ACE\u2010I cough was 37% of 13.5% reported cases on ACE\u2010I, while 8.5% reported cases on placebo were equivalent to 63% of cases on ACE\u2010I, indicating potential other factors for cough than ACE\u2010I in a substantial number of cough cases on ACE\u2010I. Placebo\u2010adjusted ACE\u2010I cough had the highest rates of arterial hypertension (85%) and the lowest of heart failure (29%). Therefore, other causes of cough, particularly in heart failure, should be excluded before ACE\u2010I withdrawal.<\/jats:p>","DOI":"10.1002\/cpt.1018","type":"journal-article","created":{"date-parts":[[2018,1,13]],"date-time":"2018-01-13T13:47:07Z","timestamp":1515851227000},"page":"652-660","source":"Crossref","is-referenced-by-count":27,"title":["Rate of Cough During Treatment With Angiotensin\u2010Converting Enzyme Inhibitors: A Meta\u2010Analysis of Randomized Placebo\u2010Controlled Trials"],"prefix":"10.1111","volume":"105","author":[{"given":"Davor","family":"Vukadinovi\u0107","sequence":"first","affiliation":[{"name":"Universit\u00e4t des Saarlandes, Klinik f\u00fcr Innere Medizin III  Homburg\/Saar Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra Nikolovska","family":"Vukadinovi\u0107","sequence":"additional","affiliation":[{"name":"Universit\u00e4t des Saarlandes, Klinik f\u00fcr Innere Medizin III  Homburg\/Saar Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Lavall","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Leipzig, Klinik und Poliklinik f\u00fcr Kardiologie  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Laufs","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Leipzig, Klinik und Poliklinik f\u00fcr Kardiologie  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Wagenpfeil","sequence":"additional","affiliation":[{"name":"Universit\u00e4t des Saarlandes, Institut f\u00fcr Medizinische Biometrie, Epidemiologie und Medizinische Informatik  Homburg\/Saar Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"B\u00f6hm","sequence":"additional","affiliation":[{"name":"Universit\u00e4t des Saarlandes, Klinik f\u00fcr Innere Medizin III  Homburg\/Saar Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,8]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht151"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv320"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs215"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw128"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-016-9575-2"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1998.1481"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108013250501"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S25976"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06178-5"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042167"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200401000-00032"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3282ff8864"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1000482"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(97)00372-5"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.18.2217"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200001203420301"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042739"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)01461-8"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.86.1.100"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14286-9"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.6.659"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199209033271002"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.685073"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/hj.1998.v136.89745"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199512213332503"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199209033271001"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199209033271003"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.all.0000136759.43571.7f"},{"key":"e_1_2_8_29_1","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1183\/09031936.93.06040576","article-title":"Kinins and respiratory tract diseases","volume":"6","author":"Trifilieff A.","year":"1993","journal-title":"Eur. 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