{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T22:52:12Z","timestamp":1769640732026,"version":"3.49.0"},"reference-count":5,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T00:00:00Z","timestamp":1521763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>The United States has the ignominious distinction of leading the world in opioid prescribing,<jats:sup>1<\/jats:sup> and in opioid\u2010related overdose deaths. The Centers for Disease Control (CDC) estimates that over 40,000 people died of an opioid\u2010related overdose, with fentanyl\u2010related deaths exceeding those of heroin or prescription opioids.<jats:sup>2<\/jats:sup> Opioid overdoses are now the leading cause of unintentional deaths in the US and of declining lifespan expectancies.<jats:sup>3<\/jats:sup> With a worsening crisis, agencies of the US government and others produced an array of reports on the opioid crisis. Yet the death rate escalated further from 2010 to the present.<\/jats:p>","DOI":"10.1002\/cpt.1050","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T19:20:52Z","timestamp":1521832852000},"page":"943-945","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["The President's Commission on Combating Drug Addiction and the Opioid Crisis: Origins and Recommendations"],"prefix":"10.1111","volume":"103","author":[{"given":"Bertha K.","family":"Madras","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Harvard Medical School, Divisions of Alcohol Drug Abuse and Basic Neuroscience Research Belmont Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,23]]},"reference":[{"key":"e_1_2_9_1_1","first-page":"427","volume":"390","author":"Humphreys K.","year":"2017","journal-title":"Avoiding globalization of the prescription opioid epidemic (comment)"},{"key":"e_1_2_9_2_1","unstructured":"Centers for Disease Control Provisional counts of drug overdose deaths as of 8 July 2017 <https:\/\/www.cdc.gov\/nchs\/data\/health_policy\/monthly-drug-overdose-death-estimates.pdf>. Accessed 21 December 2018."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.9308"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2017.0163"},{"key":"e_1_2_9_5_1","unstructured":"The President's Commission on Combating Drug Addiction and the Opioid Crisis. <https:\/\/www.whitehouse.gov\/sites\/whitehouse.gov\/files\/images\/Final_Report_Draft_11-15-2017.pdf> (2017). Accessed 20 December 2018."}],"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt.1050","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt.1050","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cpt.1050","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt.1050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:28:44Z","timestamp":1699363724000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt.1050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,23]]},"references-count":5,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1002\/cpt.1050"],"URL":"https:\/\/doi.org\/10.1002\/cpt.1050","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,23]]},"assertion":[{"value":"2018-01-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}