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Low\u2010density lipoprotein cholesterol (<jats:styled-content style=\"fixed-case\">LDL\u2010C<\/jats:styled-content>) has been implicated as one of the major risk factors causing <jats:styled-content style=\"fixed-case\">ASCVD<\/jats:styled-content> based on multiple hierarchical levels of evidence. The advent of powerful <jats:styled-content style=\"fixed-case\">LDL\u2010C<\/jats:styled-content> lowering therapies, such as the proprotein convertase subtilisin\/kexin type 9 inhibitor, have raised the question of how low to target <jats:styled-content style=\"fixed-case\">LDL\u2010C<\/jats:styled-content> and whether there are any adverse safety events associated with a very low <jats:styled-content style=\"fixed-case\">LDL\u2010C<\/jats:styled-content> level. 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