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The current study assessed the relationship between ivermectin blood concentrations and the observed mosquitocidal effects against <jats:italic>Anopheles gambiae s.s<\/jats:italic>. Three days of ivermectin 0, 300, or 600\u00a0mcg\/kg\/day plus <jats:styled-content style=\"fixed-case\">DP<\/jats:styled-content> was randomly assigned to 141 adults with uncomplicated malaria in Kenya. During 28 days of follow\u2010up, 1,393 venous and 335 paired capillary plasma samples, 850 mosquito\u2010cluster mortality rates, and 524 <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>cF\u2010intervals were collected. Using pharmacokinetic\/pharmacodynamic (<jats:styled-content style=\"fixed-case\">PK<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>) modeling, we show a consistent correlation between predicted ivermectin concentrations and observed mosquitocidal\u2010effects throughout the 28\u2010day study duration, without invoking an unidentified mosquitocidal metabolite or drug\u2010drug interaction. Ivermectin had no effect on piperaquine's PKs or <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>cF\u2010prolongation. The <jats:styled-content style=\"fixed-case\">PK<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> model can be used to design new treatment regimens with predicted mosquitocidal effect. This methodology could be used to evaluate effectiveness of other endectocides.<\/jats:p>","DOI":"10.1002\/cpt.1219","type":"journal-article","created":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T09:43:28Z","timestamp":1534758208000},"page":"388-401","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Pharmacokinetics\u2010Pharmacodynamics of High\u2010Dose Ivermectin with Dihydroartemisinin\u2010Piperaquine on Mosquitocidal Activity and <scp>QT<\/scp>\u2010Prolongation (<scp>IVERMAL<\/scp>)"],"prefix":"10.1111","volume":"105","author":[{"given":"Menno R.","family":"Smit","sequence":"first","affiliation":[{"name":"Liverpool School of Tropical Medicine (LSTM)  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric O.","family":"Ochomo","sequence":"additional","affiliation":[{"name":"Kenya Medical Research Institute (KEMRI) Centre for Global Health Research  Kisumu Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Waterhouse","sequence":"additional","affiliation":[{"name":"Liverpool School of Tropical Medicine (LSTM)  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Titus K.","family":"Kwambai","sequence":"additional","affiliation":[{"name":"Liverpool School of Tropical Medicine (LSTM)  Liverpool UK"},{"name":"Kenya Medical Research Institute (KEMRI) Centre for Global Health Research  Kisumu Kenya"},{"name":"Kenya Ministry of Health (MoH), Kisumu County  Kisumu Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard O.","family":"Abong'o","sequence":"additional","affiliation":[{"name":"Kenya Medical Research Institute (KEMRI) Centre for Global Health Research  Kisumu Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teun","family":"Bousema","sequence":"additional","affiliation":[{"name":"Radboud University Nijmegen Medical Center (Radboud)  Nijmegen The Netherlands"},{"name":"London School of Hygiene and Tropical Medicine (LSHTM)  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabie M.","family":"Bayoh","sequence":"additional","affiliation":[{"name":"US Centers for Disease Control and Prevention (CDC), Center for Global Health, Division of Parasitic Diseases and Malaria  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Gimnig","sequence":"additional","affiliation":[{"name":"US Centers for Disease Control and Prevention (CDC), Center for Global Health, Division of Parasitic Diseases and Malaria  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron M.","family":"Samuels","sequence":"additional","affiliation":[{"name":"US Centers for Disease Control and Prevention (CDC), Center for Global Health, Division of Parasitic Diseases and Malaria  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghna R.","family":"Desai","sequence":"additional","affiliation":[{"name":"US Centers for Disease Control and Prevention (CDC), Center for Global Health, Division of Parasitic Diseases and Malaria  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penelope A.","family":"Phillips\u2010Howard","sequence":"additional","affiliation":[{"name":"Liverpool School of Tropical Medicine (LSTM)  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon K.","family":"Kariuki","sequence":"additional","affiliation":[{"name":"Kenya Medical Research Institute (KEMRI) Centre for Global Health Research  Kisumu Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duolao","family":"Wang","sequence":"additional","affiliation":[{"name":"Liverpool School of Tropical Medicine (LSTM)  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiko O.","family":"ter Kuile","sequence":"additional","affiliation":[{"name":"Liverpool School of Tropical Medicine (LSTM)  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen A.","family":"Ward","sequence":"additional","affiliation":[{"name":"Liverpool School of Tropical Medicine (LSTM)  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghaith","family":"Aljayyoussi","sequence":"additional","affiliation":[{"name":"Liverpool School of Tropical Medicine (LSTM)  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,9]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw416"},{"issue":"5","key":"e_1_2_10_2_1","first-page":"411","article-title":"Mass drug administration and reactive case detection for malaria elimination. 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