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To compare the risks of allopurinol hypersensitivity and febuxostat hypersensitivity and cardiovascular diseases (<jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>s) in Asians, we conducted a population\u2010based cohort study enrolling patients receiving allopurinol or febuxostat from Chang Gung Memorial Hospital Health System across Taiwan during 2012\u20132016 and further performed a meta\u2010analysis incorporating two recent studies. Among the 61,539 users, a corresponding 12,007 and 5,680 patients were identified as new users. The overall incidence of febuxostat hypersensitivity was significantly lower than allopurinol hypersensitivity (0.2 vs. 2.7 per 1,000 new users; <jats:italic>P\u00a0&lt;\u00a0<\/jats:italic>0.001). There were 33 allopurinol\u2010hypersensitivity reactions (including 18 severe cutaneous adverse drug reactions), and only one patient developed febuxostat\u2010maculopapular exanthema. Moreover, febuxostat did not statistically increase the risk of <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content> (hazard ratio (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>), 1.16; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.152) and related death (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>, 1.49; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.496) compared to allopurinol. The result of the meta\u2010analysis also showed a consistent result. In conclusion, the incidence and severity of febuxostat\u2010hypersensitivity are lower than with allopurinol. Febuxostat did not show an increased risk of <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content> and related death.<\/jats:p>","DOI":"10.1002\/cpt.1377","type":"journal-article","created":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T22:49:02Z","timestamp":1548715742000},"page":"391-401","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Hypersensitivity and Cardiovascular Risks Related to Allopurinol and Febuxostat Therapy in Asians: A Population\u2010Based Cohort Study and Meta\u2010Analysis"],"prefix":"10.1111","volume":"106","author":[{"given":"Chi\u2010Hua","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pharmacy Chang Gung Memorial Hospital  Linkou Taiwan"},{"name":"School of Pharmacy College of Pharmacy Taipei Medical University  Taipei 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