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Matched QT<\/jats:styled-content> and plasma drug concentrations (11,925) from 1,114 subjects were pooled from 5 studies in OUD<\/jats:styled-content>. A concentration\u2010QT<\/jats:styled-content> model was developed, which accounted for confounding factors (e.g., comedications) affecting heart rate and heart rate\u2010corrected QT<\/jats:styled-content> interval (QT<\/jats:styled-content>c). Bias\u2010corrected nonparametric two\u2010sided 90% confidence intervals (CI<\/jats:styled-content>s) were derived for the mean predicted effect of BUP<\/jats:styled-content>\u2010XR<\/jats:styled-content> on QT<\/jats:styled-content>c (\u0394QT<\/jats:styled-content>c) at therapeutic and supratherapeutic doses. Changes in QT<\/jats:styled-content>c were associated with age, central vs. noncentral reading, sex, methadone, and barbiturates. The upper 90% CI<\/jats:styled-content> of \u0394QT<\/jats:styled-content>c was 0.29, 0.67, and 1.34\u00a0ms at the steady\u2010state peak concentration (Cmax<\/jats:sub>) for 100, 300, and 2\u00a0\u00d7\u00a0300 mg doses, respectively. An effect of BUP<\/jats:styled-content>\u2010XR<\/jats:styled-content> on QT<\/jats:styled-content> can be ruled out at therapeutic and supratherapeutic doses of BUP<\/jats:styled-content>\u2010XR<\/jats:styled-content>, after accounting for covariates that may influence heart rate and QT<\/jats:styled-content> interval in OUD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1002\/cpt.1406","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T02:27:05Z","timestamp":1551148025000},"page":"576-584","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Evaluation of the Effects of a Monthly Buprenorphine Depot Subcutaneous Injection on QT<\/scp> Interval During Treatment for Opioid Use Disorder"],"prefix":"10.1111","volume":"106","author":[{"given":"Virginia D.","family":"Schmith","sequence":"first","affiliation":[{"name":"Nuventra Pharma Sciences Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Curd","sequence":"additional","affiliation":[{"name":"Nuventra Pharma Sciences Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren R. 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Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,8]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.22.2469"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2009.02549.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2012.09.016"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1G524"},{"key":"e_1_2_10_5_1","unstructured":"US Food and Drug Administration (FDA).Clinical pharmacology and biopharmaceutics review \u2013 BuTrans. Food and Drug Administration (2010)."},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2012.02.023"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32259-1"},{"key":"e_1_2_10_8_1","unstructured":"SublocadeTM[package insert]. 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