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Efavirenz is predominantly metabolized into inactive metabolites by cytochrome P450 (CYP)2B6, and patients with certain <jats:italic>CYP2B6<\/jats:italic> genetic variants may be at increased risk for adverse effects, particularly central nervous system toxicity and treatment discontinuation. We summarize the evidence from the literature and provide therapeutic recommendations for efavirenz prescribing based on <jats:italic>CYP2B6<\/jats:italic> genotypes.<\/jats:p>","DOI":"10.1002\/cpt.1477","type":"journal-article","created":{"date-parts":[[2019,4,21]],"date-time":"2019-04-21T14:23:42Z","timestamp":1555856622000},"page":"726-733","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":185,"title":["Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for <i>CYP2B6<\/i> and Efavirenz\u2010Containing Antiretroviral Therapy"],"prefix":"10.1111","volume":"106","author":[{"given":"Zeruesenay","family":"Desta","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Clinical Pharmacology Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roseann S.","family":"Gammal","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice Massachusetts College of Pharmacy and Health Sciences University School of Pharmacy  Boston Massachusetts USA"},{"name":"Department of Pharmaceutical Sciences St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data Science Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Whirl\u2010Carrillo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data Science Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya H.","family":"Gaur","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chonlaphat","family":"Sukasem","sequence":"additional","affiliation":[{"name":"Division of Pharmacogenomics and Personalized Medicine Faculty of Medicine Ramathibodi Hospital Department of Pathology Mahidol University  Bangkok Thailand"},{"name":"Laboratory for Pharmacogenomics Faculty of Medicine Ramathibodi Hospital Somdech Phra Debaratana Medical Center  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Hockings","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Genomic Medicine Institute Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Myers","sequence":"additional","affiliation":[{"name":"Department of Diagnostic &amp; 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