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We used new\u2010initiator, active\u2010comparator cohort designs to investigate these drugs in two data sources. We adjusted for confounders using stabilized inverse\u2010probability\u2010of\u2010treatment weights and evaluated results using \u201cintention\u2010to\u2010treat\u201d and \u201cas\u2010treated\u201d follow\u2010up approaches. In both data sources, Kaplan\u2013Meier curves showed trends for more rapid progression to glaucoma filtration surgery in patients taking calcium channel blockers compared with thiazides with as\u2010treated (MarketScan <jats:italic>P<\/jats:italic>\u00a0=\u00a00.15; Medicare <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03) and intention\u2010to\u2010treat follow\u2010up (MarketScan <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01; Medicare <jats:italic>P<\/jats:italic>\u00a0=\u00a00.10). There was suggestion of delayed progression for selective serotonin reuptake inhibitor compared with tricyclic antidepressants in Medicare, which was not observed in MarketScan. Our study provided support for a relationship between calcium channel blockers and <jats:styled-content style=\"fixed-case\">OAG<\/jats:styled-content> progression but not for other investigated drugs.<\/jats:p>","DOI":"10.1002\/cpt.1490","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T03:14:10Z","timestamp":1556680450000},"page":"874-883","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Using Healthcare Databases to Refine Understanding of Exploratory Associations Between Drugs and Progression of Open\u2010Angle Glaucoma"],"prefix":"10.1111","volume":"106","author":[{"given":"Shirley V.","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Pharmacoepidemiology and Pharmacoeconomics Department of Medicine Brigham and Women's Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Novartis Institutes for Biomedical Research  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis S.","family":"Rice","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Novartis Institutes for Biomedical Research  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia L.","family":"Grosskreutz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Novartis Institutes for Biomedical Research  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaddeus P.","family":"Dryja","sequence":"additional","affiliation":[{"name":"Massachusetts Eye and Ear Infirmary  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesh","family":"Prasanna","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Novartis Institutes for Biomedical Research  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Lii","sequence":"additional","affiliation":[{"name":"Division of Pharmacoepidemiology and Pharmacoeconomics Department of Medicine Brigham and Women's Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua J.","family":"Gagne","sequence":"additional","affiliation":[{"name":"Division of Pharmacoepidemiology and Pharmacoeconomics Department of Medicine Brigham and Women's Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,14]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2011-300539"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(13)70113-X"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.05.013"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.081224"},{"key":"e_1_2_9_5_1","unstructured":"Jacobs D.Open\u2010angle glaucoma: epidemiology clinical presentation and diagnosis. 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