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This population pharmacokinetic (PK)\u2010pharmacodynamic study included 131 <jats:styled-content style=\"fixed-case\">SAM<\/jats:styled-content> and 266 non\u2010<jats:styled-content style=\"fixed-case\">SAM<\/jats:styled-content> children administered artemether\u2010lumefantrine twice daily for 3\u00a0days. Lumefantrine capillary plasma concentrations were adequately described by two transit\u2010absorption compartments followed by two distribution compartments. Allometrically scaled body weight and an enzymatic maturation effect were included in the PK model. Mid\u2010upper arm circumference was associated with decreased absorption of lumefantrine (25.4% decreased absorption per 1\u00a0cm reduction). Risk of recurrent malaria episodes (i.e., reinfection) were characterized by an interval\u2010censored time\u2010to\u2010event model with a sigmoid maximum\u2010effect model describing the effect of lumefantrine. <jats:styled-content style=\"fixed-case\">SAM<\/jats:styled-content> children were at risk of underexposure to lumefantrine and an increased risk of malaria reinfection compared with well\u2010nourished children. Research on optimized regimens should be considered for malaria treatment in malnourished children.<\/jats:p>","DOI":"10.1002\/cpt.1531","type":"journal-article","created":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T11:35:14Z","timestamp":1559388914000},"page":"1299-1309","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Severe Acute Malnutrition Results in Lower Lumefantrine Exposure in Children Treated With Artemether\u2010Lumefantrine for Uncomplicated Malaria"],"prefix":"10.1111","volume":"106","author":[{"given":"Palang","family":"Chotsiri","sequence":"first","affiliation":[{"name":"Mahidol\u2010Oxford Tropical Medicine Research Unit Faculty of Tropical Medicine Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise","family":"Denoeud\u2010Ndam","sequence":"additional","affiliation":[{"name":"Epicentre  Paris 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