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Forty\u2010two patients with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> were randomized to either weekly\u00a0intravenous infusions of <jats:styled-content style=\"fixed-case\">NAC<\/jats:styled-content> (50\u00a0mg\/kg) plus oral doses (500\u00a0mg twice per day) for 3\u00a0months or standard of care only. Participants received prebrain and postbrain imaging with ioflupane (DaTscan) to measure dopamine transporter (<jats:styled-content style=\"fixed-case\">DAT<\/jats:styled-content>) binding. In the <jats:styled-content style=\"fixed-case\">NAC<\/jats:styled-content> group, significantly increased <jats:styled-content style=\"fixed-case\">DAT<\/jats:styled-content> binding was found in the caudate and putamen (mean increase from 3.4% to 8.3%) compared with controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), along with significantly improved <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> symptoms (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). The results suggest <jats:styled-content style=\"fixed-case\">NAC<\/jats:styled-content> may positively affect the dopaminergic system in patients with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>, with corresponding positive clinical effects. Larger scale studies are warranted.<\/jats:p>","DOI":"10.1002\/cpt.1548","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T18:58:40Z","timestamp":1560797920000},"page":"884-890","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":123,"title":["N\u2010Acetyl Cysteine Is Associated With Dopaminergic Improvement in Parkinson's Disease"],"prefix":"10.1111","volume":"106","author":[{"given":"Daniel A.","family":"Monti","sequence":"first","affiliation":[{"name":"Department of Integrative Medicine and Nutritional Sciences Thomas Jefferson University Philadelphia Pennsylvania USA"},{"name":"Marcus Institute of Integrative Health Thomas Jefferson University Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Zabrecky","sequence":"additional","affiliation":[{"name":"Department of Integrative Medicine and Nutritional Sciences Thomas Jefferson 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