{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T08:28:02Z","timestamp":1781857682061,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T00:00:00Z","timestamp":1563840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>The association between estrogen\u2010containing oral contraceptives and history of pregnancies with disease severity in women with polycystic liver disease (<jats:styled-content style=\"fixed-case\">PLD<\/jats:styled-content>) is unclear. We performed a cross\u2010sectional cohort study to assess this association by selecting female patients with <jats:styled-content style=\"fixed-case\">PLD<\/jats:styled-content> of which imaging was available prior to any liver volume\u2010reducing therapy. Patients received a questionnaire to collect detailed information on estrogen use and pregnancies. Preplanned subgroup analyses were performed on premenopausal and postmenopausal patients. The questionnaire was returned by 287 of 360 selected patients (80%). There was no significant association between estrogen\u2010containing oral contraceptives and height\u2010adjusted total liver volume (<jats:styled-content style=\"fixed-case\">hTLV<\/jats:styled-content>) in the total group (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.06) and postmenopausal subgroup (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.7). By contrast, each year of exposure corresponds with a 1.45% higher <jats:styled-content style=\"fixed-case\">hTLV<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.02) in the premenopausal subgroup, equivalent to a 15.5% higher <jats:styled-content style=\"fixed-case\">hTLV<\/jats:styled-content> for every 10\u00a0years of use. Pregnancy duration was not associated with <jats:styled-content style=\"fixed-case\">hTLV<\/jats:styled-content>. In conclusion, patients with <jats:styled-content style=\"fixed-case\">PLD<\/jats:styled-content> should avoid exogenous estrogens.<\/jats:p>","DOI":"10.1002\/cpt.1553","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T18:51:04Z","timestamp":1560797464000},"page":"1338-1345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Estrogen\u2010Containing Oral Contraceptives Are Associated With Polycystic Liver Disease Severity in Premenopausal Patients"],"prefix":"10.1111","volume":"106","author":[{"given":"Ren\u00e9 M.M.","family":"van Aerts","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas H.P.","family":"Bernts","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom J.G.","family":"Gevers","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wietske","family":"Kievit","sequence":"additional","affiliation":[{"name":"Department for Health Evidence Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisanne","family":"Koopmans","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodoor E.","family":"Nieboer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Nevens","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospital Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8027-3073","authenticated-orcid":false,"given":"Joost P.H.","family":"Drenth","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,23]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00080605"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12430"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640617705577"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13965"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.11.024"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70425-4"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.04.055"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510260528"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.07.051"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfw008"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640615618042"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182342b7f"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.02.047"},{"key":"e_1_2_9_14_1","first-page":"741","article-title":"Estrogen and sex hormone\u2010binding globulin levels in nulliparous and parous women","volume":"74","author":"Bernstein L.","year":"1985","journal-title":"J. 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