{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:52:22Z","timestamp":1791935542044,"version":"4.3.4"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T00:00:00Z","timestamp":1568073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>We conducted a prospective evaluation of drug\u2010induced severe hyponatremia\u00a0 (adverse drug reaction (ADR)) through the Prospective Pharmacovigilance Program from Laboratory Signals at Hospital over a period of 10\u00a0years. Cases of serum sodium (Na(s))\u00a0&lt;\u00a0116\u00a0mM were recorded from July 2007 to June 2017 (first period). Also cases of Na(s) 116\u2013122\u00a0mM were recorded from July 2012 to June 2017 (second period). Drugs were the primary cause of severe hyponatremia. The incidence rate of Na(s)\u00a0&lt;\u00a0116\u00a0mM by drugs was increased threefold over the decade. Compared with other causes of hyponatremia, patients with adverse drug reaction\u2013serum sodium (ADR\u2010Na(s)) in the first period were older (79\u00a0years (interquartile range (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>) 68.6\u201389 vs. 65\u00a0years (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 48\u201381); <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001) and were more often women (70.8% vs. 48.9% men, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001); in the second period were also older (79\u00a0years (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 65.3\u201389) vs. 63\u00a0years (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 46\u201380.6); <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001) and were more often women (70% vs. 53%, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.002), and ADR\u2010Na(s) occurred more often in summer. The most frequent therapeutic groups of culprit drugs were the cardiovascular system and nervous system. The 65.3% in the first period and 71.2% in the second period of the ADR\u2010Na(s) cases responded to hydration and had been diagnosed with hypovolemic hyponatremia.<\/jats:p>","DOI":"10.1002\/cpt.1562","type":"journal-article","created":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T16:03:04Z","timestamp":1561651384000},"page":"1362-1379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Severe Hyponatremia Is Often Drug Induced: 10\u2010Year Results of a Prospective Pharmacovigilance Program"],"prefix":"10.1111","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4052-8876","authenticated-orcid":false,"given":"Elena","family":"Ram\u00edrez","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology La Paz University Hospital\u2010Carlos III IdiPAZ School of Medicine Autonomous University of Madrid Madrid 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