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To compare the effects of ticagrelor\u2010monotherapy with ticagrelor\u2010based DAPT on hemostatic system activation, we conducted a randomized controlled trial in 44 volunteers using a loading\u2010dose regimen and measured platelet\u2010aggregometry triggered by adenosine diphosphate (multiple electrode aggregometry (MEA)\u2010ADP) and arachidonic acid (MEA\u2010AA), the vasodilator\u2010stimulated phosphoprotein (VASP), prothrombin fragment 1.2 (f1.2), and d\u2010Dimer. Ticagrelor\u2010based DAPT and ticagrelor\u2010monotherapy significantly decreased MEA\u2010ADP (\u0394mean: \u221251.4 (\u221256.9; \u221245.8) and \u221246.2 (\u221251.7; \u221240.7)) and VASP (\u0394mean: \u221270.3 (\u221276.2; \u221264.4) and \u221269.6 (\u221275.5; \u221263.7)) at 2\u00a0hours and over 24\u00a0hours. MEA\u2010AA was reduced significantly by both treatments (\u0394mean: \u221272.9 (\u221280.6; \u221265.3) and \u221225.7 (\u221233.3; \u221218.0)) at 2\u00a0hours, and stronger by ticagrelor\u2010based DAPT over 24\u00a0hours. Both treatments decreased f1.2 (geometric mean ratio (GMR): 0.92 (0.84; 1.01) and 0.88 (0.80; 0.96)) and d\u2010Dimer (GMR: 0.89 (0.86; 0.92) and 0.91 (0.88; 0.94)) at 2\u00a0hours and d\u2010Dimer over 24\u00a0hours. Ticagrelor\u2010monotherapy and ticagrelor\u2010based DAPT comparably affect hemostatic system activation.<\/jats:p>","DOI":"10.1002\/cpt.1616","type":"journal-article","created":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T18:43:53Z","timestamp":1566585833000},"page":"415-422","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Differential Effects of Ticagrelor With or Without Aspirin on Platelet Reactivity and Coagulation Activation: A Randomized Trial in Healthy Volunteers"],"prefix":"10.1111","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2861-5771","authenticated-orcid":false,"given":"Ludwig","family":"Traby","sequence":"first","affiliation":[{"name":"Department of Medicine I Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marietta","family":"Kollars","sequence":"additional","affiliation":[{"name":"Department of Medicine I 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