{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:07:32Z","timestamp":1791270452287,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T00:00:00Z","timestamp":1574208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:p>The goal of ulcerative colitis (<jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>) treatment has recently been shown to be \u201cmucosal healing,\u201d as no drug directly induces mucosal healing. Probiotics possess sufficient safety, but their efficacy in the treatment of <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content> remains controversial because of the influence of intestinal conditions. It is believed that the identification of bioactive molecules produced by probiotics and their application will help to solve this issue. We therefore identified a probiotic\u2010derived long\u2010chain polyphosphate as a molecule enhancing the intestinal barrier function. This study demonstrated that long\u2010chain polyphosphate exhibited antiinflammatory effects in a human macrophage and <jats:styled-content style=\"fixed-case\">interleukin<\/jats:styled-content>\u201010 <jats:styled-content style=\"fixed-case\">knockout<\/jats:styled-content> transfusion mouse model. The first\u2010in\u2010human trial showed that 7 of the 10 enrolled patients acquired clinical remission, 4 of whom achieved endoscopic remission despite a history of treatment with anti\u2013<jats:styled-content style=\"fixed-case\">tumor necrosis factor (TNF)<\/jats:styled-content>\u2013\u03b1 agents. No adverse reactions were observed. Long\u2010chain polyphosphate might be useful for the treatment of refractory <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>, even in patients with failure or intolerance to anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 therapy.<\/jats:p>","DOI":"10.1002\/cpt.1628","type":"journal-article","created":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T13:43:15Z","timestamp":1568295795000},"page":"452-461","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Long\u2010Chain Polyphosphate Is a Potential Agent for Inducing Mucosal Healing of the Colon in Ulcerative Colitis"],"prefix":"10.1111","volume":"107","author":[{"given":"Mikihiro","family":"Fujiya","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hematology\/Oncology Department of Medicine Asahikawa Medical University Asahikawa 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