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In asthma, although lung function and asthma control improvements are commonplace with placebo, pharmacogenomics of placebo vs. drug response remains unexamined. In a genomewide association study of subjective and objective outcomes with placebo treatment in Childhood Asthma Management Program of nedocromil\/budesonide vs. placebo (<jats:italic>N<\/jats:italic>\u00a0=\u00a0604), effect estimates for lead single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) were compared across arms. The coughing\/wheezing lead <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>, rs2392165 (\u03b2\u00a0=\u00a00.94; <jats:italic>P<\/jats:italic>\u00a0=\u00a01.10E\u201007) mapped to <jats:italic><jats:styled-content style=\"fixed-case\">BBS<\/jats:styled-content>9<\/jats:italic>, a gene implicated in lung development that contains a lung function expression quantitative trait locus. The effect was attenuated with budesonide (<jats:italic>P<\/jats:italic><jats:sub>interaction<\/jats:sub>\u00a0=\u00a01.48E\u201007), but not nedocromil (<jats:italic>P<\/jats:italic><jats:sub>interaction<\/jats:sub>\u00a0=\u00a00.06). The lead forced vital capacity <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>, rs12930749 (\u03b2\u00a0=\u00a0\u22125.80; <jats:italic>P<\/jats:italic>\u00a0=\u00a01.47E\u201006), mapped to <jats:italic><jats:styled-content style=\"fixed-case\">KIAA<\/jats:styled-content>0556<\/jats:italic>, a locus genomewide associated with respiratory diseases. The rs12930749 effect was attenuated with budesonide (<jats:italic>P<\/jats:italic><jats:sub>interaction<\/jats:sub>\u00a0=\u00a01.32E\u201002) and nedocromil (<jats:italic>P<\/jats:italic><jats:sub>interaction<\/jats:sub>\u00a0=\u00a01.09E\u201002). Pharmacogenomic analysis revealed differential effects with placebo and drug treatment that could potentially guide precision drug development in asthma.<\/jats:p>","DOI":"10.1002\/cpt.1646","type":"journal-article","created":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T01:27:32Z","timestamp":1569547652000},"page":"1261-1267","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Pharmacogenomics and Placebo Response in a Randomized Clinical Trial in Asthma"],"prefix":"10.1111","volume":"106","author":[{"given":"Rui\u2010Sheng","family":"Wang","sequence":"first","affiliation":[{"name":"Channing Division of Network Medicine Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damien C.","family":"Croteau\u2010Chonka","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edwin K.","family":"Silverman","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Loscalzo","sequence":"additional","affiliation":[{"name":"Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott T.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn T.","family":"Hall","sequence":"additional","affiliation":[{"name":"Division of Preventive Medicine Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,28]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.irn.2018.07.021"},{"key":"e_1_2_9_2_1","article-title":"COMT and alpha\u2010tocopherol effects in cancer prevention: gene\u2010supplement interactions in two randomized clinical trials","author":"Hall K.T.","journal-title":"J. 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