{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:23:38Z","timestamp":1790681018614,"version":"4.1.0"},"reference-count":100,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T00:00:00Z","timestamp":1575590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI16\/0967"],"award-info":[{"award-number":["PI16\/0967"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:p>\n                    One of the most used painkillers is acetaminophen (APAP), which is safe at the right dose. However, several studies have described populations susceptible to APAP\u2010induced liver damage, mainly in livers with steatosis. Thus, clinicians should consider the presence of obesity and other chronic liver diseases like nonalcoholic fatty liver disease (NAFLD) when indicating treatment with APAP. Liver damage from this drug is generated through its metabolite\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetyl\u2010p\u2010benzoquinone imine, which is detoxified with glutathione (GSH). Prior depletion of GSH in steatotic hepatocytes plays a key role in APAP\u2010induced hepatotoxicity in people with obesity and NAFLD. The knowledge about the damage to the liver or APAP in susceptible people like the obese and those with NAFLD is of great relevance for the sanitary sector because it would imply strategies of different therapeutic approach in such patients. This paper reviews the role of APAP in liver damage in the presence of obesity, NAFLD, and nonalcoholic steatohepatitis.\n                  <\/jats:p>","DOI":"10.1002\/cpt.1701","type":"journal-article","created":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T05:50:22Z","timestamp":1571723422000},"page":"1068-1081","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Acetaminophen\u2010Induced Liver Damage in Hepatic Steatosis"],"prefix":"10.1111","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6802-1188","authenticated-orcid":false,"given":"Rebeca","family":"Garc\u00eda\u2010Rom\u00e1n","sequence":"first","affiliation":[{"name":"Public Health Institute Veracruzana University Xalapa Veracruz Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5105-1201","authenticated-orcid":false,"given":"Rub\u00e9n","family":"Franc\u00e9s","sequence":"additional","affiliation":[{"name":"Liver and Intestinal Immunobiology Group Department of Clinical Medicine Miguel Hern\u00e1ndez University San Juan Alicante Spain"},{"name":"ISABIAL\u2010FISABIO Foundation General University Hospital of Alicante Alicante Spain"},{"name":"CIBERehd Health Institute Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,6]]},"reference":[{"key":"e_1_2_12_1_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5512.497"},{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-013-1007-6"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22536"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.112.193813"},{"issue":"2","key":"e_1_2_12_5_1","doi-asserted-by":"crossref","first-page":"S93","DOI":"10.33549\/physiolres.932395","article-title":"Steatotic rat hepatocytes in primary culture are more susceptible to the acute toxic effect of acetaminophen","volume":"61","author":"Kucera O.","year":"2012","journal-title":"Physiol. Res."},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20466"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.09.038"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0234-x"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.25540"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20080253"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-1212"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.05.011"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.56.657.459"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12635"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2008.892"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aep322"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.27.9.1219"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2011.03993.x"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600520911"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00607678"},{"key":"e_1_2_12_21_1","first-page":"998","article-title":"Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP\u2010glucuronosyltransferase isoforms","volume":"299","author":"Court M.H.","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-017-2356-6"},{"key":"e_1_2_12_23_1","first-page":"43","article-title":"Acetaminophen and phenol: substrates for both a thermostable and a thermolabile form of human platelet phenol sulfotransferase","volume":"221","author":"Reiter C.","year":"1982","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20535"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/03602532.2010.527984"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/00498250802512830"},{"key":"e_1_2_12_27_1","first-page":"1397","article-title":"Involvement of human cytochrome P450 2D6 in the bioactivation of acetaminophen","volume":"28","author":"Dong H.","year":"2000","journal-title":"Drug Metab. Dispos."},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26134"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(88)90592-9"},{"key":"e_1_2_12_30_1","first-page":"211","article-title":"Acetaminophen\u2010induced hepatic necrosis. IV. Protective role of glutathione","volume":"187","author":"Mitchell J.R.","year":"1973","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-11-20"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2014.09.002"},{"key":"e_1_2_12_33_1","first-page":"749","article-title":"Plasma glutathione and glutathione disulfide in the rat: regulation and response to oxidative stress","volume":"227","author":"Adams J.D.","year":"1983","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.34943"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24132"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfg220"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(79)80069-1"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(96)03831-3"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)39733-9"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2011.02501.x"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfw158"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00453"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.088898"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2016.10.001"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12514"},{"key":"e_1_2_12_46_1","first-page":"921","article-title":"Obesity as a risk factor in drug\u2010induced organ injury: increased liver and kidney damage by acetaminophen in the obese overfed rat","volume":"241","author":"Corcoran G.B.","year":"1987","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00361.2009"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.06807.x"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2015.12.020"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20030285"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70160-X"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2015.03.019"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19103005"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20437"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2005.07.003"},{"key":"e_1_2_12_56_1","article-title":"The impact of steatosis on liver regeneration","author":"Allaire M.","journal-title":"Horm. Mol. Biol. Clin. Investig."},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.7194"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.15698\/cst2018.07.144"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.06.004"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i15.1622"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v10.i1.8"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.3727\/105221618X15205260749346"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfw213"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2018.12.006"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1159\/000374090"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2011.03.001"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2014.01.004"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.30956"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0308173"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24690"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.04.005"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13866"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.02.005"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181f9b3a0"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.114.062703"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-0667-6_99"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4339"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.07.014"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mjt.0000434043.62372.00"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042098612464265"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2016.1150302"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12527"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-015-1774-6"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2005-0494"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060519833527"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.011"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.933592"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.105858"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i19.2300"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/79.3.502"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.1999.01822.x"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2003.09.020"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.091016398"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.2001.5266"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.050953"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hepres.2006.01.003"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81294-5"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00199.2004"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.20.3182"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000278"}],"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt.1701","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt.1701","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cpt.1701","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt.1701","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T08:36:38Z","timestamp":1699346198000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt.1701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,6]]},"references-count":100,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1002\/cpt.1701"],"URL":"https:\/\/doi.org\/10.1002\/cpt.1701","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,6]]},"assertion":[{"value":"2019-06-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}