{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T02:06:27Z","timestamp":1791511587377,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T00:00:00Z","timestamp":1577750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004409","name":"Doctors Without Borders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:p>Poor adherence to seasonal malaria chemoprevention (SMC) might affect the protective effectiveness of SMC. Here, we evaluated the population pharmacokinetic properties of amodiaquine and its active metabolite, desethylamodiaquine, in children receiving SMC under directly observed ideal conditions (<jats:italic>n<\/jats:italic>\u00a0=\u00a0136), and the adherence of SMC at an implementation phase in children participating in a case\u2010control study to evaluate SMC effectiveness (<jats:italic>n<\/jats:italic>\u00a0=\u00a0869). Amodiaquine and desethylamodiaquine concentration\u2010time profiles were described simultaneously by two\u2010compartment and three\u2010compartment disposition models, respectively. The developed methodology to evaluate adherence showed a sensitivity of 65\u201371% when the first dose of SMC was directly observed and 71\u201373% when no doses were observed in a routine programmatic setting. Adherence simulations and measured desethylamodiaquine concentrations in the case\u2010control children showed complete adherence (all doses taken) in &lt;\u00a020% of children. This result suggests that more efforts are needed urgently to improve the adherence to SMC among children in this area.<\/jats:p>","DOI":"10.1002\/cpt.1707","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T17:34:09Z","timestamp":1572024849000},"page":"1179-1188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Adherence and Population Pharmacokinetic Properties of Amodiaquine When Used for Seasonal Malaria Chemoprevention in African Children"],"prefix":"10.1111","volume":"107","author":[{"given":"Junjie","family":"Ding","sequence":"first","affiliation":[{"name":"Centre for Tropical Medicine and Global Health Nuffield Department of Clinical Medicine University of Oxford Oxford UK"},{"name":"The WorldWide Antimalarial Resistance Network Oxford UK"},{"name":"Children's Hospital of Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew E.","family":"Coldiron","sequence":"additional","affiliation":[{"name":"Epicentre Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bachir","family":"Assao","sequence":"additional","affiliation":[{"name":"Epicentre Maradi Niger"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ousmane","family":"Guindo","sequence":"additional","affiliation":[{"name":"Epicentre Maradi Niger"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Blessborn","sequence":"additional","affiliation":[{"name":"Centre for Tropical Medicine and Global Health Nuffield Department of Clinical Medicine University of Oxford Oxford UK"},{"name":"Mahidol\u2010Oxford Tropical Medicine Research Unit Faculty of Tropical Medicine Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Winterberg","sequence":"additional","affiliation":[{"name":"Centre for Tropical Medicine and Global Health Nuffield Department of Clinical Medicine University of Oxford Oxford UK"},{"name":"Mahidol\u2010Oxford Tropical Medicine Research Unit Faculty of Tropical Medicine Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca F.","family":"Grais","sequence":"additional","affiliation":[{"name":"Epicentre Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alena","family":"Koscalova","sequence":"additional","affiliation":[{"name":"M\u00e9decins Sans Fronti\u00e8res Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine","family":"Langendorf","sequence":"additional","affiliation":[{"name":"Epicentre Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Tarning","sequence":"additional","affiliation":[{"name":"Centre for Tropical Medicine and Global Health Nuffield Department of Clinical Medicine University of Oxford Oxford UK"},{"name":"The WorldWide Antimalarial Resistance Network Oxford UK"},{"name":"Mahidol\u2010Oxford Tropical Medicine Research Unit Faculty of Tropical Medicine Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,31]]},"reference":[{"key":"e_1_2_11_1_1","volume-title":"Seasonal malaria chemoprevention with sulfadoxine\u2010pyrimethamine plus amodiaquine in children: a field guide","author":"World Health Organization (WHO)","year":"2013"},{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2006.01657.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.300.2.399"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100122"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00673-07"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-8-200"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2004.02257.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10928-007-9064-2"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00679-09"},{"key":"e_1_2_11_10_1","article-title":"Population pharmacokinetic properties of sulfadoxine and pyrimethamine: a pooled analysis to inform optimal dosing in African children with uncomplicated malaria","volume":"62","author":"Kock M.","year":"2018","journal-title":"Antimicrob. 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