{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:47:12Z","timestamp":1792028832267,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T00:00:00Z","timestamp":1576022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:p>Prospective data of vedolizumab treatment for patients with inflammatory bowel disease (IBD) beyond 1\u00a0year of treatment is scarce but needed for clinical decision making. We prospectively enrolled 310 patients with IBD (191 with Crohn's disease (CD) and 119 patients with ulcerative colitis (UC)) with a follow\u2010up period of 104\u00a0weeks (interquartile range: 103\u2013104) in a nationwide registry. The corticosteroid\u2010free clinical remission rate (Harvey Bradshaw Index\u00a0\u2264\u00a04, Short Clinical Colitis Activity index\u00a0\u2264\u00a02) at weeks 52 and 104 were 28% and 19% for CD and 27% and 28% for UC, respectively. Fifty\u2010nine percent maintained corticosteroid\u2010free clinical remission between weeks 52 and 104. Vedolizumab with concomitant immunosuppression showed comparable effectiveness outcomes compared with vedolizumab monotherapy (week 104: 21% vs. 23%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.77), whereas 8 of 13 severe infections occurred in patients treated with concomitant immunosuppression. To conclude, the clinical effect was 19% for CD and 28% for UC after 2\u00a0years of follow\u2010up regardless of concomitant immunosuppression.<\/jats:p>","DOI":"10.1002\/cpt.1712","type":"journal-article","created":{"date-parts":[[2019,11,2]],"date-time":"2019-11-02T07:23:12Z","timestamp":1572679392000},"page":"1189-1199","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Vedolizumab for Inflammatory Bowel Disease: Two\u2010Year Results of the\u00a0Initiative on Crohn and Colitis (ICC) Registry, A Nationwide Prospective Observational Cohort Study"],"prefix":"10.1111","volume":"107","author":[{"given":"Vince B.C.","family":"Biemans","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Radboud University Medical Centre Nijmegen The Netherlands"},{"name":"Department of Gastroenterology and Hepatology Maastricht University Medical Centre Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Janneke","family":"van der Woude","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus Medical Centre Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Dijkstra","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Medical Centre Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea E.","family":"van der Meulen\u2010de Jong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Leiden University Medical Centre Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bas","family":"Oldenburg","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Medical Centre Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanne K.","family":"de Boer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amsterdam University Medical Centre Vrije Universiteit Amsterdam The Netherlands"},{"name":"Amsterdam Gastroenterology &amp; Metabolism Research Institute Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"L\u00f6wenberg","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amsterdam University Medical Centre Academic Medical Centre Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidhi","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Haaglanden Medical Centre the Hague The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander G.L.","family":"Bodelier","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amphia Hospital Breda The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel L.","family":"West","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Franciscus Gasthuis &amp; Vlietland Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen M.","family":"Jansen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Onze Lieve Vrouwe Gasthuis Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie C.","family":"de Vries","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus Medical Centre Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeoffrey J.L.","family":"Haans","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Maastricht University Medical Centre Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk J.","family":"de Jong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Radboud University Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie J.","family":"Pierik","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Maastricht University Medical Centre Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Hoentjen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Radboud University Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,11]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215734"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215739"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.02.004"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.236"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41395-018-0162-0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13813"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-017-4549-3"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2017.1304987"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14167"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14930"},{"key":"e_1_2_8_11_1","first-page":"400","article-title":"Long\u2010term efficacy of vedolizumab for ulcerative colitis","volume":"11","author":"Loftus E.V.","year":"2017","journal-title":"J. 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