{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:20:00Z","timestamp":1762917600252,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T00:00:00Z","timestamp":1437523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HD047905, HD047891, HD047892"],"award-info":[{"award-number":["HD047905, HD047891, HD047892"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>Pregnancy heightens the risk of adverse outcomes from influenza infections. This is true for both seasonal epidemics as well as occasional pandemics. Seasonal influenza vaccines are the focus of disease prevention and are recommended for all pregnant women in any trimester of pregnancy and postpartum. Oseltamivir (Tamiflu) is currently the recommended and most commonly used pharmaceutical agent for influenza prophylaxis and treatment. Oseltamivir has been demonstrated to prevent disease after exposure, treat infected individuals, as well as lessen the likelihood of complications. The physiologic adaptations of pregnancy alter the pharmacokinetics of this important drug. Evidence of these alterations, knowledge gaps, and future investigative directions to fill these knowledge gaps are highlighted.<\/jats:p>","DOI":"10.1002\/cpt.179","type":"journal-article","created":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T07:19:21Z","timestamp":1435216761000},"page":"403-405","source":"Crossref","is-referenced-by-count":10,"title":["Oseltamivir for the treatment of H1N1 influenza during pregnancy"],"prefix":"10.1111","volume":"98","author":[{"given":"RH","family":"Beigi","sequence":"first","affiliation":[{"name":"Department of Obstetrics Gynecology and Reproductive Sciences Magee\u2010Womens Hospital of the University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"},{"name":"Magee\u2010Womens Research Institute, University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VC","family":"Pillai","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences School of Pharmacy, School of Medicine, University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Venkataramanan","sequence":"additional","affiliation":[{"name":"Magee\u2010Womens Research Institute, University of Pittsburgh Pittsburgh Pennsylvania USA"},{"name":"Department of Pharmaceutical Sciences School of Pharmacy, School of Medicine, University of Pittsburgh Pittsburgh Pennsylvania USA"},{"name":"Department of Pathology School of Medicine, University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SN","family":"Caritis","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Gynecology and Reproductive Sciences Magee\u2010Womens Hospital of the University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"},{"name":"Magee\u2010Womens Research Institute, University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,22]]},"reference":[{"key":"e_1_2_6_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2014.08.002"},{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200326110-00004"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199937060-00003"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200544100-00001"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.03.002"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12691"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.03.005"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.30.1.13"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100126"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2165\/11536370-000000000-00000"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.090866"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181d44752"},{"issue":"293","key":"e_1_2_6_13_1","first-page":"e1","article-title":"Infant outcomes among pregnant women who used oseltamivir for treatment of influenza during the H1N1 epidemic","volume":"208","author":"Xie H.Y.","year":"2013","journal-title":"Am. J. Obstet. Gynecol."},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.04.007"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis265"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2012.693993"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00167-09"}],"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt.179","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt.179","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:31:58Z","timestamp":1699363918000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt.179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,22]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1002\/cpt.179"],"URL":"https:\/\/doi.org\/10.1002\/cpt.179","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"type":"print","value":"0009-9236"},{"type":"electronic","value":"1532-6535"}],"subject":[],"published":{"date-parts":[[2015,7,22]]}}}