{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T15:22:28Z","timestamp":1785943348854,"version":"3.56.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,2,23]],"date-time":"2020-02-23T00:00:00Z","timestamp":1582416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["KLI 340"],"award-info":[{"award-number":["KLI 340"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:p>It has been hypothesized that besides its intraocular pressure (IOP) lowering potential, tetrahydrocannabinol (THC) may also improve ocular hemodynamics. The aim of the present study was to investigate whether single oral administration of dronabinol, a synthetic THC, alters optic nerve head blood flow (ONHBF) and its regulation in healthy subjects. The study was carried out in a randomized, placebo\u2010controlled, double\u2010masked, two\u2010way crossover design in 24 healthy subjects. For each study participant, 2\u00a0study days were scheduled, on which they either received capsules containing 5\u00a0mg dronabinol or placebo. ONHBF was measured with laser Doppler flowmetry at rest and while the study participants performed isometric exercise for 6\u00a0minutes to increase mean arterial blood pressure (MAP). This was repeated 1\u00a0hour after drug intake. Ocular perfusion pressure (OPP) was calculated as 2\/3MAP\u2013IOP. Dronabinol was well tolerated and no cannabinoid\u2010related psychoactive effects were reported. Neither administration of dronabinol nor placebo had an effect on IOP, MAP, or OPP. In contrast, dronabinol significantly increased ONHBF at rest by 9.5\u00a0\u00b1\u00a08.1%, whereas placebo did not show a change in ONHBF (0.3\u00a0\u00b1\u00a07.4% vs. baseline, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001 between study days). Dronabinol did not alter the autoregulatory response of ONHBF to isometric exercise. In conclusion, the present data indicate that low\u2010dose dronabinol increases ONHBF in healthy subjects without affecting IOP, OPP, or inducing psychoactive side effects. In addition, dronabinol does not alter the autoregulatory response of ONHBF to an experimental increase in OPP. Further studies are needed to investigate whether this effect can also be observed in patients with glaucoma.<\/jats:p>","DOI":"10.1002\/cpt.1797","type":"journal-article","created":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T14:09:17Z","timestamp":1579874957000},"page":"155-161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The Effect of Orally Administered Dronabinol on Optic Nerve Head Blood Flow in Healthy Subjects\u2014A Randomized Clinical Trial"],"prefix":"10.1111","volume":"108","author":[{"given":"Nikolaus","family":"Hommer","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Kallab","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Medical University of Vienna Vienna 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