{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T13:29:31Z","timestamp":1792762171106,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T00:00:00Z","timestamp":1588032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R24GM115264"],"award-info":[{"award-number":["R24GM115264"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U24HG010135"],"award-info":[{"award-number":["U24HG010135"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R24GM61374"],"award-info":[{"award-number":["R24GM61374"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U24HG010615"],"award-info":[{"award-number":["U24HG010615"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:p>\n                    Nonsteroidal anti\u2010inflammatory drugs (NSAIDs) are among the most commonly used analgesics due to their lack of addictive potential. However, NSAIDs have the potential to cause serious gastrointestinal, renal, and cardiovascular adverse events.\n                    <jats:italic>CYP2C9<\/jats:italic>\n                    polymorphisms influence metabolism and clearance of several drugs in this class, thereby affecting drug exposure and potentially safety. We summarize evidence from the published literature supporting these associations and provide therapeutic recommendations for NSAIDs based on\n                    <jats:italic>CYP2C9<\/jats:italic>\n                    genotype (updates at\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.cpicpgx.org\">www.cpicpgx.org<\/jats:ext-link>\n                    ).\n                  <\/jats:p>","DOI":"10.1002\/cpt.1830","type":"journal-article","created":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T03:35:31Z","timestamp":1584588931000},"page":"191-200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":345,"title":["Clinical Pharmacogenetics Implementation Consortium Guideline (CPIC) for\n                    <i>CYP2C9<\/i>\n                    and Nonsteroidal Anti\u2010Inflammatory Drugs"],"prefix":"10.1111","volume":"108","author":[{"given":"Katherine N.","family":"Theken","sequence":"first","affiliation":[{"name":"Institute for Translational Medicine and Therapeutics Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig R.","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Pharmacotherapy and Experimental Therapeutics Eshelman School of Pharmacy University of North Carolina Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data Science and Department of Medicine Stanford University Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly E.","family":"Caudle","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences St. Jude Children\u2019s Research Hospital Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M.","family":"Formea","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Center for Individualized Medicine Mayo Clinic Rochester Minnesota USA"},{"name":"Department of Pharmacy and Intermountain Precision Genomics Intermountain Healthcare Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gaedigk","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology Toxicology &amp; Therapeutic Innovation Children's Mercy Kansas City Kansas City Missouri USA"},{"name":"School of Medicine University of Missouri-Kansas City Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teri E.","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data Science and Department of Medicine Stanford University Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.G.","family":"Ag\u00fandez","sequence":"additional","affiliation":[{"name":"University Institute of Molecular Pathology Biomarkers UEx. ARADyAL Instituto de Salud Carlos III C\u00e1ceres Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilo","family":"Grosser","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine and Therapeutics Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,28]]},"reference":[{"key":"e_1_2_11_1_1","unstructured":"Clinical Pharmacogenetics Implementation Consortium (CPIC).CPIC Guideline for NSAIDs based on CYP2C9 genotype<https:\/\/cpicpgx.org\/cpic\u2010guideline\u2010for\u2010nsaids\u2010based\u2010on\u2010cyp2c9\u2010genotype\/>."},{"key":"e_1_2_11_2_1","unstructured":"Pharmacogenomics Knowledgebase (PharmGKB).Gene\u2010specific Information Tables for CYP2C9<https:\/\/www.pharmgkb.org\/page\/cyp2c9RefMaterials>."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200204000-00010"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2014.159"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120403"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-008-9781-2"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-008-0584-5"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.668"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ympev.2018.03.037"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2009.10"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.794"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27291"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3463"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.2009.062166"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.7205\/MILMED-D-16-00183"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199835050-00003"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000840"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-011209-153129"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60900-9"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.636746"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.080754"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03261999"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2004.12.005"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.004671"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(00)00682-3"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.15.40"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-015-0580-0"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2011.00751.x"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.105.003616"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2004.04.006"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200308000-00005"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-003-0574-6"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.105.006452"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0000000000000025"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2005.06.005"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03256232"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/pmj.2003.006478"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH03-05-0325"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2005.02.009"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1613616"}],"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt.1830","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt.1830","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cpt.1830","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt.1830","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T08:37:40Z","timestamp":1699346260000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt.1830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,28]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1002\/cpt.1830"],"URL":"https:\/\/doi.org\/10.1002\/cpt.1830","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,28]]},"assertion":[{"value":"2019-12-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}