{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T08:43:20Z","timestamp":1784191400929,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T00:00:00Z","timestamp":1587254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:p>In a pooled population analysis, we investigated the pharmacokinetics of i.v. anidulafungin in four studies across a full range of adult and pediatric ages in patients with confirmed, suspected, or at high risk of invasive candidiasis (IC). Relationships between anidulafungin exposure and key efficacy end points (global response of success and all\u2010cause mortality) and safety end points (all\u2010cause hepatic or gastrointestinal adverse events) in all patients and separately in pediatric patients and the appropriate dosing regimen for IC treatment in pediatric patients were evaluated. Pediatric patients received a 3.0\u00a0mg\/kg (maximum 200\u00a0mg) i.v. loading dose and 1.5\u00a0mg\/kg (maximum 100\u00a0mg) daily thereafter. Adults received a 200\u00a0mg i.v. loading dose and 100\u00a0mg daily thereafter. Estimated systemic anidulafungin exposures were similar across age groups (neonates to adults) at the weight\u2010based doses studied in pediatric patients. No clear associations were identified between anidulafungin exposure and efficacy or safety end points.<\/jats:p>","DOI":"10.1002\/cpt.1831","type":"journal-article","created":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T08:46:03Z","timestamp":1584607563000},"page":"316-325","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Population Analysis of Anidulafungin in Infants to Older Adults With Confirmed or Suspected Invasive Candidiasis"],"prefix":"10.1111","volume":"108","author":[{"given":"Rujia","family":"Xie","sequence":"first","affiliation":[{"name":"Pharmacometrics Pfizer Asia Manufacturing Pte Ltd Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"McFadyen","sequence":"additional","affiliation":[{"name":"Pharmacometrics Pfizer Research and Development UK Ltd Kent UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Raber","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Pfizer Inc La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Swanson","sequence":"additional","affiliation":[{"name":"Clinical Research and Development Pfizer Inc Groton Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Tawadrous","sequence":"additional","affiliation":[{"name":"Global Product Development Pfizer Inc Groton Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Leister\u2010Tebbe","sequence":"additional","affiliation":[{"name":"Clinical Research and Development Pfizer Inc Groton Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Cohen\u2010Wolkowiez","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Durham North Carolina USA"},{"name":"Department of Pediatrics Duke University Medical Center Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Daniel K.","family":"Benjamin","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Durham North Carolina USA"},{"name":"Department of Pediatrics Duke University Medical Center Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Liu","sequence":"additional","affiliation":[{"name":"Formerly Clinical Pharmacology, Development China Pfizer Inc Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,19]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1315399"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/496922"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/376906"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000039"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.04.034"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2292"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12039"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12041"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ933"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12040"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.3.634"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2011.26"},{"key":"e_1_2_10_13_1","unstructured":"Pfizer Inc. 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