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Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for major depressive disorder (MDD). This study aims to investigate the efficacy of magnetic resonance imaging (MRI)\u2010based neuronavigation\u2010guided daily high\u2010dose rTMS for rapidly improving suicidal ideation in treatment\u2010naive patients with MDD. In the present 1\u2010week double\u2010blind study, 42 treatment\u2010naive patients with MDD with suicidal ideation were randomly assigned to the treatment of escitalopram oxalate tablets (10\u00a0mg\/d) in combination with either active (<jats:italic>n<\/jats:italic>\u00a0=\u00a021) or sham (<jats:italic>n<\/jats:italic>\u00a0=\u00a021) rTMS. The TMS coil was positioned over a specified target location (\u221244, 40, and 29) in left dorsolateral prefrontal cortex based on MRI data. The severity of suicidal ideation was measured by the Beck Scale for Suicide Ideation (BSI). The 24\u2010item Hamilton Depression Rating Scale (HAMD\u201024) and Montgomery\u2013\u00c5sberg Depression Rating Scale (MADRS) were utilized to assess the severity of depression. The Wisconsin Card Sorting Test, Continuous Performance Test, and Stroop Color\u2013Word Test were adopted to assess executive function. In contrast to the sham group, the active rTMS group showed a significantly greater BSI score reduction at the third day and the seventh day (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Moreover, the active rTMS group showed a significantly greater HAMD (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and MADRS (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) score reduction at the seventh day in comparison to the sham group. The present findings suggested that the neuronavigation\u2010guided high\u2010dose rTMS may be a novel method to rapidly reduce suicidal ideation and mitigate depressive symptoms.<\/jats:p>","DOI":"10.1002\/cpt.1858","type":"journal-article","created":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T10:11:31Z","timestamp":1587550291000},"page":"826-832","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["Neuronavigation\u2010Guided rTMS for the Treatment of Depressive Patients With Suicidal Ideation: A Double\u2010Blind, Randomized, Sham\u2010Controlled Trial"],"prefix":"10.1111","volume":"108","author":[{"given":"Fen","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Psychiatry First Affiliated Hospital College of Medicine Zhejiang University Hangzhou China"},{"name":"The Key Laboratory of Mental Disorder\u2019s Management of Zhejiang Province Hangzhou 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