{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:11:37Z","timestamp":1780636297007,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T00:00:00Z","timestamp":1595289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:p>Co\u2010trimoxazole (CTX) causes various forms of severe cutaneous adverse reactions (SCARs). This case\u2010control study was conducted to investigate the involvement between genetic variants of human leukocyte antigen (<jats:italic>HLA<\/jats:italic>) and <jats:italic>CYP2C9<\/jats:italic> in CTX\u2010induced SCARs, including Stevens\u2010Johnson syndrome (SJS)\/toxic epidermal necrolysis (TEN) and drug reaction with eosinophilia and systemic symptoms (DRESS) in Thai patients. Thirty cases of CTX\u2010induced SCARs were enrolled and compared with 91 CTX\u2010tolerant controls and 150 people from the general Thai population. Cases comprised 18 SJS\/TEN and 12 DRESS patients. This study demonstrated that genetic association of CTX\u2010induced SCARs was phenotype\u2010specific. <jats:italic>HLA\u2010B*15:02<\/jats:italic> and <jats:italic>HLA\u2010C*08:01<\/jats:italic> alleles were significantly associated with CTX\u2010induced SJS\/TEN, whereas the <jats:italic>HLA\u2010B*13:01<\/jats:italic> allele was significantly associated with CTX\u2010induced DRESS. In addition, a significant higher frequency of <jats:italic>HLA\u2010A*11:01\u2010B*15:02<\/jats:italic> and <jats:italic>HLA\u2010B*13:01\u2010C*03:04<\/jats:italic> haplotypes were detected in the group of CTX\u2010induced Stevens\u2010Johnson syndrome\/toxic epidermal necrolysis (SJS\/TEN) and DRESS cases, respectively. Genetic association of CTX\u2010induced SCARs is phenotype\u2010specific. Interestingly, these association was observed only in HIV\u2010infected patients but not in non\u2010HIV\u2010infected patients.<\/jats:p>","DOI":"10.1002\/cpt.1915","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T08:50:12Z","timestamp":1590483012000},"page":"1078-1089","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Genetic Association of Co\u2010Trimoxazole\u2010Induced Severe Cutaneous Adverse Reactions Is Phenotype\u2010Specific: HLA Class I Genotypes and Haplotypes"],"prefix":"10.1111","volume":"108","author":[{"given":"Chonlaphat","family":"Sukasem","sequence":"first","affiliation":[{"name":"Division of Pharmacogenomics and Personalized Medicine Department of Pathology Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"},{"name":"Laboratory for Pharmacogenomics Somdech Phra Debaratana Medical Center (SDMC) Ramathibodi Hospital Bangkok 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