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To identify genetic polymorphisms that contribute to the variability in AED\u2010MS response, we performed a discovery genome\u2010wide association study (GWAS) of 199 BD patients from the Mayo Clinic Bipolar Disorder Biobank. Most of these patients had been treated with the AED\u2010MS valproate\/divalproex and\/or lamotrigine. AED\u2010MS response was assessed using the Alda scale, which quantifies clinical improvement while accounting for potential confounding factors. We identified two genome\u2010wide significant single\u2010nucleotide polymorphism (SNP) signals that mapped to the <jats:italic>THSD7A<\/jats:italic> (rs78835388, <jats:italic>P<\/jats:italic>\u00a0=\u00a07.1E\u201009) and <jats:italic>SLC35F3<\/jats:italic> (rs114872993, <jats:italic>P<\/jats:italic>\u00a0=\u00a03.2E\u201008) genes. We also identified two genes with statistically significant gene\u2010level associations: <jats:italic>ABCC1<\/jats:italic> (<jats:italic>P<\/jats:italic>\u00a0=\u00a06.7E\u201007; top SNP rs875740, <jats:italic>P<\/jats:italic>\u00a0=\u00a02.0E\u20106), and <jats:italic>DISP1<\/jats:italic> (<jats:italic>P<\/jats:italic>\u00a0=\u00a08.9E\u201007; top SNP rs34701716, <jats:italic>P<\/jats:italic>\u00a0=\u00a08.9E\u201007). <jats:italic>THSD7A<\/jats:italic> SNPs were previously found to be associated with risk for several psychiatric disorders, including BD. Both <jats:italic>THSD7A<\/jats:italic> and <jats:italic>SLC35F3<\/jats:italic> are expressed in excitatory\/glutamatergic and inhibitory\/\u03b3\u2010aminobutyric acidergic (GABAergic) neurons, which are targets of AED\u2010MSs. <jats:italic>ABCC1<\/jats:italic> is involved in the transport of valproate and lamotrigine metabolites, and the SNPs in <jats:italic>ABCC1<\/jats:italic> and <jats:italic>DISP1<\/jats:italic> with the strongest evidence of association in our GWAS are strong splicing quantitative trait loci in the human gut, suggesting a possible influence on drug absorption. In conclusion, our pharmacogenomic study identified novel genetic loci that appear to contribute to AED\u2010MS treatment response, and may facilitate precision medicine in BD.<\/jats:p>","DOI":"10.1002\/cpt.1982","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T03:14:22Z","timestamp":1594005262000},"page":"1233-1242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Mood\u2010Stabilizing Antiepileptic Treatment Response in Bipolar Disorder: A Genome\u2010Wide Association Study"],"prefix":"10.1111","volume":"108","author":[{"given":"Ada Man\u2010Choi","family":"Ho","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychology Mayo Clinic Rochester Minnesota USA"},{"name":"Department of Molecular Pharmacology &amp; Experimental Therapeutics Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon J.","family":"Coombes","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thanh Thanh L.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology &amp; Experimental Therapeutics Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology &amp; Experimental Therapeutics Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan L.","family":"McElroy","sequence":"additional","affiliation":[{"name":"Lindner Center of HOPE\/University of Cincinnati Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balwinder","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malik","family":"Nassan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin L.","family":"Colby","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth R.","family":"Larrabee","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard M.","family":"Weinshilboum","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology &amp; Experimental Therapeutics Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Frye","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna M.","family":"Biernacka","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology Mayo Clinic Rochester Minnesota USA"},{"name":"Department of Health Sciences Research Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,7]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40345-016-0068-y"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1000402"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1430"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1074"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/10673229609030527"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00143-4"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2008.09.011"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.08m04632gre"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065636"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40345-015-0030-4"},{"key":"e_1_2_10_11_1","unstructured":"First M.B. 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