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Most PPIs are metabolized primarily by cytochrome P450 2C19 (CYP2C19) into inactive metabolites, and\n                    <jats:italic>CYP2C19<\/jats:italic>\n                    genotype has been linked to PPI exposure, efficacy, and adverse effects. We summarize the evidence from the literature and provide therapeutic recommendations for PPI prescribing based on\n                    <jats:italic>CYP2C19<\/jats:italic>\n                    genotype (updates at\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.cpicpgx.org\">www.cpicpgx.org<\/jats:ext-link>\n                    ). The potential benefits of using\n                    <jats:italic>CYP2C19<\/jats:italic>\n                    genotype data to guide PPI therapy include (i) identifying patients with genotypes predictive of lower plasma exposure and prescribing them a higher dose that will increase the likelihood of efficacy, and (ii) identifying patients on chronic therapy with genotypes predictive of higher plasma exposure and prescribing them a decreased dose to minimize the risk of toxicity that is associated with long\u2010term PPI use, particularly at higher plasma concentrations.\n                  <\/jats:p>","DOI":"10.1002\/cpt.2015","type":"journal-article","created":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T09:06:48Z","timestamp":1596877608000},"page":"1417-1423","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":306,"title":["Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for\n                    <i>CYP2C19<\/i>\n                    and Proton Pump Inhibitor Dosing"],"prefix":"10.1111","volume":"109","author":[{"given":"John J.","family":"Lima","sequence":"first","affiliation":[{"name":"Center for Pharmacogenomics and Translational Research Nemours Children\u2019s Health Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron D.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research, and Center for Pharmacogenomics and Precision Medicine College of Pharmacy University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Barbarino","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data Science Stanford University Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeruesenay","family":"Desta","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Clinical Pharmacology Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara L.","family":"Van Driest","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Medicine Vanderbilt University School of Medicine Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihal","family":"El Rouby","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research, and Center for Pharmacogenomics and Precision Medicine College of Pharmacy University of Florida Gainesville Florida USA"},{"name":"Division of Pharmacy Practice &amp; Administrative Sciences University of Cincinnati James Winkle College of Pharmacy Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research, and Center for Pharmacogenomics and Precision Medicine College of Pharmacy University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larisa H.","family":"Cavallari","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research, and Center for Pharmacogenomics and Precision Medicine College of Pharmacy University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Shakhnovich","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Toxicology, and Therapeutic Innovation Children\u2019s Mercy Kansas City and University of Missouri Kansas City School of Medicine Kansas City Missouri USA"},{"name":"Division of Gastroenterology, Hepatology, and Nutrition Children\u2019s Mercy Kansas City Kansas City Missouri USA"},{"name":"Center for Children\u2019s Healthy Lifestyles &amp; Nutrition Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Thacker","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Indiana University School of Medicine Indianapolis Indiana USA"},{"name":"Translational Software Bellevue Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart A.","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York New York USA"},{"name":"Sema4 Stamford Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Schwab","sequence":"additional","affiliation":[{"name":"Dr Margarete Fischer\u2010Bosch\u2010Institute of Clinical Pharmacology Stuttgart Germany"},{"name":"Department of Clinical Pharmacology University Hospital Tuebingen Germany"},{"name":"Department of Pharmacy and Biochemistry University of Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chakradhara Rao S.","family":"Uppugunduri","sequence":"additional","affiliation":[{"name":"CANSEARCH Research Laboratory Department of Pediatrics, Gynecology, and Obstetrics Faculty of Medicine University of Geneva Geneva Switzerland"},{"name":"Oncology\u2010Hematology Unit Department of Pediatrics, Gynecology, and Obstetrics Geneva University Hospital Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M.","family":"Formea","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services and Intermountain Precision Genomics Intermountain Healthcare Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Franciosi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition Nemours Children\u2019s Hospital Orlando Florida USA"},{"name":"Department of Pediatrics University of Central Florida College of Medicine Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Sangkuhl","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data Science Stanford University Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gaedigk","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Toxicology, and Therapeutic Innovation Children\u2019s Mercy Kansas City and University of Missouri Kansas City School of Medicine Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teri E.","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data Science Stanford University Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roseann S.","family":"Gammal","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice MCPHS University School of Pharmacy Boston Massachusetts USA"},{"name":"Department of Pharmaceutical Sciences St Jude Children\u2019s Research Hospital Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahisa","family":"Furuta","sequence":"additional","affiliation":[{"name":"Center for Clinical Research Hamamatsu University School of Medicine Hamamatsu Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,20]]},"reference":[{"key":"e_1_2_11_1_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2018.1461835"},{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042098618809927"},{"key":"e_1_2_11_3_1","unstructured":"ClinicalPharmacogeneticsImplementation Consortium (CPIC).CPIC Guideline for Proton Pump Inhibitors and CYP2C19<https:\/\/cpicpgx.org\/guidelines\/cpic\u2010guideline\u2010for\u2010proton\u2010pump\u2010inhibitors\u2010and\u2010cyp2c19\/> (2020)."},{"key":"e_1_2_11_4_1","unstructured":"Pharmacogenomics Knowledgebase (PharmGKB).Gene\u2010specific Information Tables for CYP2C19<https:\/\/www.pharmgkb.org\/page\/cyp2c19RefMaterials>. 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