{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T18:05:24Z","timestamp":1784311524628,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,10,25]],"date-time":"2020-10-25T00:00:00Z","timestamp":1603584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:p>Oral breast cancer prevention medications entail systemic exposure, limiting acceptance by high\u2010risk women. Delivery through the breast skin, although an attractive alternative, requires demonstration of drug distribution throughout the breast. We conducted a randomized double\u2010blind, placebo\u2010controlled phase II clinical trial comparing telapristone acetate, a progesterone receptor antagonist, administered orally (12\u00a0mg\/day) or transdermally (12\u00a0mg\/breast) for 4\u00a0\u00b1\u00a01\u00a0weeks to women planning mastectomy. Plasma and tissue concentrations, measured at five locations in the mastectomy specimen using liquid chromatography tandem mass spectrometry were compared. In 60 evaluable subjects, median drug concentration (ng\/g tissue) was 103 (interquartile range (IQR): 46.3\u2013336) in the oral vs. 2.82 (IQR: 1.4\u20135.5) in the transdermal group. Despite poor dermal permeation, within\u2010breast drug distribution pattern was identical in both groups (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.88, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.006), demonstrating that transdermally and orally delivered drug is distributed similarly through the breast, and is strongly influenced by tissue adiposity (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). Other skin\u2010penetrant drugs should be tested for breast cancer prevention.<\/jats:p>","DOI":"10.1002\/cpt.2041","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T12:55:33Z","timestamp":1601470533000},"page":"728-738","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Local Transdermal Delivery of Telapristone Acetate Through Breast Skin, Compared With Oral Treatment: A Randomized Double\u2010Blind, Placebo\u2010Controlled Phase II Trial"],"prefix":"10.1111","volume":"109","author":[{"given":"Oukseub","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Surgery Northwestern University Feinberg School of Medicine Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Pilewskie","sequence":"additional","affiliation":[{"name":"Department of Surgery Memorial Sloan Kettering Cancer Center New York New York 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