{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:03:59Z","timestamp":1772118239148,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T00:00:00Z","timestamp":1601856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:p>This study aimed to investigate whether specific medications used in the treatment chronic diseases affected either the development and\/ or severity of coronavirus disease 2019 (COVID\u201019) in a cohort of 610 COVID\u201019 cases and 48,667 population\u2010based controls from Zhejiang, China. Using a cohort of 578 COVID\u201019 cases and 48,667 population\u2010based controls from Zhejiang, China, we tested the role of usage of cardiovascular, antidiabetic, and other medications on risk and severity of COVID\u201019. Analyses were adjusted for age, sex, and body mass index and for presence of relevant comorbidities. Individuals with hypertension taking calcium channel blockers had significantly increased risk (odds ratio (OR)\u00a0=\u00a01.73, 95% confidence interval (CI) 1.2\u20132.3) of manifesting symptoms of COVID\u201019, whereas those taking angiotensin receptor blockers and diuretics had significantly lower disease risk (OR\u00a0=\u00a00.22, 95% CI 0.15\u20130.30 and OR\u00a0=\u00a00.30, 95% CI 0.19\u20130.58, respectively). Among those with type 2 diabetes, dipeptidyl peptidase\u20104 inhibitors (OR\u00a0=\u00a06.02, 95% CI 2.3\u201315.5) and insulin (OR\u00a0=\u00a02.71, 95% CI 1.6\u20135.5) were more and glucosidase inhibitors were less prevalent (OR\u00a0=\u00a00.11, 95% CI 0.1\u20130.3) among with patients with COVID\u201019. Drugs used in the treatment of hypertension and diabetes influence the risk of development of COVID\u201019, but, not its severity.<\/jats:p>","DOI":"10.1002\/cpt.2047","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T14:54:39Z","timestamp":1600700079000},"page":"1185-1194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Role of Drugs Used for Chronic Disease Management on Susceptibility and Severity of COVID\u201019: A Large Case\u2010Control Study"],"prefix":"10.1111","volume":"108","author":[{"given":"Huadong","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Hwamei Hospital Ningbo No. 2 Hospital University of Chinese Academy of Sciences Ningbo China"},{"name":"Department of New Medical Science Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province Hwamei Hospital Ningbo No. 2 Hospital University of Chinese Academy of Sciences Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana M.","family":"Valdes","sequence":"additional","affiliation":[{"name":"NIHR Nottingham Biomedical Research Centre Nottingham University Hospitals NHS Trust and University of Nottingham Nottingham UK"},{"name":"Division of Rheumatology, Orthopaedics, and Dermatology School of Medicine University of Nottingham Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amrita","family":"Vijay","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Orthopaedics, and Dermatology School of Medicine University of Nottingham Nottingham UK"},{"name":"Nottingham Digestive Diseases Centre School of Medicine University of Nottingham Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanbo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Practice Gulin Township Health Center Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Hwamei Hospital Ningbo No. 2 Hospital University of Chinese Academy of Sciences Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiqing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Hwamei Hospital Ningbo No. 2 Hospital University of Chinese Academy of Sciences Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Hwamei Hospital Ningbo No. 2 Hospital University of Chinese Academy of Sciences Ningbo China"},{"name":"Department of Infectious Diseases Ninghai No. 1 Hospital Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of General Practice Gulin Township Health Center Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyuan","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Hwamei Hospital Ningbo No. 2 Hospital University of Chinese Academy of Sciences Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susu","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Hwamei Hospital Ningbo No. 2 Hospital University of Chinese Academy of Sciences Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kecheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of General Practice Gulin Township Health Center Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanrong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Hwamei Hospital Ningbo No. 2 Hospital University of Chinese Academy of Sciences Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of New Medical Science Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province Hwamei Hospital Ningbo No. 2 Hospital University of Chinese Academy of Sciences Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanhong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Hwamei Hospital Ningbo No. 2 Hospital University of Chinese Academy of Sciences Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaoren","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Hwamei Hospital Ningbo No. 2 Hospital University of Chinese Academy of Sciences Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Hwamei Hospital Ningbo No. 2 Hospital University of Chinese Academy of Sciences Ningbo China"},{"name":"Department of New Medical Science Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province Hwamei Hospital Ningbo No. 2 Hospital University of Chinese Academy of Sciences Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guruprasad P.","family":"Aithal","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Orthopaedics, and Dermatology School of Medicine University of Nottingham Nottingham UK"},{"name":"Nottingham Digestive Diseases Centre School of Medicine University of Nottingham Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,5]]},"reference":[{"key":"e_1_2_11_1_1","unstructured":"World Health Organization (WHO) report\u201090.WHO COVID\u201019 situation report\u201090<https:\/\/www.who.int\/docs\/default\u2010source\/coronaviruse\/situation\u2010reports\/20200620\u2010covid\u201019\u2010sitrep\u2010152.pdf?sfvrsn=83aff8ee_4>. Accessed June 21 2020."},{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.2648"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2002032"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","unstructured":"Shi Q.et al.Diabetic patients with COVID\u201019 characteristics and outcome: a two\u2010centre retrospective case control study. Lancet.https:\/\/doi.org\/10.2139\/ssrn.3551369.","DOI":"10.2139\/ssrn.3551369"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30079-5"},{"key":"e_1_2_11_7_1","first-page":"1634","article-title":"Receptor and viral determinants of SARS\u2010coronavirus adaptation to human ACE2","volume":"24","author":"Li W.","year":"2005","journal-title":"Nature"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.052"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1570"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.043919-0"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000002450"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30116-8"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1313"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-020-0433-1"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr2005760"},{"key":"e_1_2_11_16_1","first-page":"1","article-title":"COVID\u201019: is there a link between the course of infection and pharmacological agents in diabetes?","volume":"3","author":"Filardi T.","year":"2020","journal-title":"J. Endocrinol. Invest."},{"key":"e_1_2_11_17_1","unstructured":"National Health Commission of the people\u2019s Republic of China.The Guidelines for the Diagnosis and Treatment of New Coronavirus Pneumonia (fifth edition)<ww.nhc.gov.cn\/yzygj\/s7653p\/202002\/3b09b894ac9b4204a79db5b8912d4440.shtml>."},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-019698"},{"key":"e_1_2_11_19_1","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1001\/jama.2020.1585","article-title":"Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus infected pneumonia in Wuhan, China","volume":"323","author":"Wang D.","year":"2018","journal-title":"JAMA"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2020.1739565"},{"key":"e_1_2_11_21_1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1128\/AAC.03999-14","article-title":"Inhibition of endoplasmic reticulum\u2010resident glucosidases impairs severe acute respiratory syndrome coronavirus and human coronavirus NL63 spike protein\u2010mediated entry by altering the glycan processing of angiotensin I\u2010converting enzyme 2","volume":"59","author":"Zhao X.","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-020-0353-9"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2521-4"},{"key":"e_1_2_11_24_1","doi-asserted-by":"crossref","unstructured":"Bozkurt B.et al.HFSA\/ACC\/AHA Statement addresses concerns re: using RAAS antagonists in COVID\u201019. American Heart Association Professional Heart Daily. March 19 (2020).","DOI":"10.1016\/j.cardfail.2020.04.013"},{"key":"e_1_2_11_25_1","first-page":"m406","article-title":"Rapid response: use of angiotensin receptor blockers such as telmisartan, losartsan in nCoV Wuhan corona virus infections \u2013 novel mode of treatment","volume":"368","author":"Phadke M.","year":"2020","journal-title":"BMJ"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.510461"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30251-8"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1267"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20040634"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e4260"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.317134"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.032380"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32478-9"},{"key":"e_1_2_11_34_1","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1080\/08998280.2018.1499293","article-title":"Impact of angiotensin\u2010converting enzyme inhibitors and statins on viral pneumonia","volume":"31","author":"Henry C.","year":"2018","journal-title":"Baylor Univ. Med. Cent. Proc."},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2008975"},{"key":"e_1_2_11_36_1","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1097\/HJH.0000000000000006","article-title":"Guidelines for the management of hypertension and target organ damage","volume":"31","author":"Mancia G.","year":"2013","journal-title":"J. Hypertens."},{"key":"e_1_2_11_37_1","unstructured":"Steiner G. S.et al.Bacterial pneumonia compared to viral pneumonia is associated with a higher risk of future major adverse cardiovascular events. Presented at: American Heart Association Scientific Sessions 2018; November 10\u201312 2018; Chicago IL <https:\/\/www.abstractsonline.com\/pp8\/#!\/4682\/presentation\/51526>."},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04574-1"},{"key":"e_1_2_11_39_1","doi-asserted-by":"crossref","first-page":"7176","DOI":"10.1038\/srep07176","article-title":"Glucocorticosteroids enhance replication of respiratory viruses: effect of adjuvant interferon","volume":"4","author":"Thomas B.","year":"2015","journal-title":"Sci. Rep."},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-020-0530-3"},{"key":"e_1_2_11_41_1","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1093\/eurheartj\/ehy881","article-title":"A novel role for myeloid endothelin\u2010B receptors in hypertension","volume":"40","author":"Czopek A.","year":"2020","journal-title":"Eur. Heart J."},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0226347"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13692"}],"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt.2047","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cpt.2047","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt.2047","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T08:38:03Z","timestamp":1699346283000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt.2047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,5]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1002\/cpt.2047"],"URL":"https:\/\/doi.org\/10.1002\/cpt.2047","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.04.24.20077875","asserted-by":"object"}]},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,5]]},"assertion":[{"value":"2020-07-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}