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At the same time, the current regulatory paradigm for screening new drugs causing long QT syndrome is preventing drugs from reaching the market, sometimes inappropriately. In this study, we report the results of a first\u2010of\u2010a\u2010kind clinical trial studying late sodium (mexiletine and lidocaine) and calcium (diltiazem) current blocking drugs to counteract the effects of hERG potassium channel blocking drugs (dofetilide and moxifloxacin). We demonstrate that both mexiletine and lidocaine substantially reduce heart\u2010rate corrected QT (QTc) prolongation from dofetilide by 20 ms. Furthermore, all QTc shortening occurs in the heart\u2010rate corrected J\u2010T<jats:sub>peak<\/jats:sub> (J\u2010T<jats:sub>peak<\/jats:sub>c) interval, the biomarker we identified as a sign of late sodium current block. This clinical trial demonstrates that late sodium blocking drugs can substantially reduce QTc prolongation from hERG potassium channel block and assessment of J\u2010T<jats:sub>peak<\/jats:sub>c may add value beyond only assessing QTc.<\/jats:p>","DOI":"10.1002\/cpt.205","type":"journal-article","created":{"date-parts":[[2015,8,11]],"date-time":"2015-08-11T08:58:53Z","timestamp":1439283533000},"page":"214-223","source":"Crossref","is-referenced-by-count":139,"title":["Late sodium current block for drug\u2010induced long QT syndrome: Results from a prospective clinical trial"],"prefix":"10.1111","volume":"99","author":[{"given":"L","family":"Johannesen","sequence":"first","affiliation":[{"name":"Center for Devices and Radiological Health US Food and Drug Administration Silver Spring Maryland USA"},{"name":"Department of Clinical Physiology Karolinska Institutet and Karolinska University Hospital Stockholm 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