{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T11:54:01Z","timestamp":1780401241587,"version":"3.54.1"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T00:00:00Z","timestamp":1605225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1002\/cpt.2089","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T19:28:37Z","timestamp":1605295717000},"page":"855-859","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Drug\u2010Drug Interactions Involving Renal OCT2\/MATE Transporters: Clinical Risk Assessment May Require Endogenous Biomarker\u2010Informed Approach"],"prefix":"10.1111","volume":"110","author":[{"given":"Sumathy","family":"Mathialagan","sequence":"first","affiliation":[{"name":"Pharmacokinetics, Dynamics, and Metabolism, Medicine Design Worldwide R&amp;D Pfizer Inc. Groton Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Feng","sequence":"additional","affiliation":[{"name":"Pharmacokinetics, Dynamics, and Metabolism, Medicine Design Worldwide R&amp;D Pfizer Inc. Groton Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. David","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Pharmacokinetics, Dynamics, and Metabolism, Medicine Design Worldwide R&amp;D Pfizer Inc. Groton Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manthena V. S.","family":"Varma","sequence":"additional","affiliation":[{"name":"Pharmacokinetics, Dynamics, and Metabolism, Medicine Design Worldwide R&amp;D Pfizer Inc. Groton Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,13]]},"reference":[{"key":"e_1_2_8_1_1","unstructured":"European Medicines Agency (EMA).Guideline on the investigation of drug interactions. Committee for Human Medicinal Products (CHMP) London UK <http:\/\/wwwemaeuropaeu\/docs\/en_GB\/document_library\/Scientific_guideline\/2012\/07\/WC500129606pdf> (2012)."},{"key":"e_1_2_8_2_1","unstructured":"US Food and Drug Administration (FDA).In Vitro Metabolism\u2010 and Transporter\u2010Mediated Drug\u2010Drug Interaction Studies Guidance for Industry.Center for Drug Evaluation and Research (CDER) Silver Spring MD(2020) <https:\/\/wwwfdagov\/regulatory\u2010information\/search\u2010fda\u2010guidance\u2010documents\/vitro\u2010drug\u2010interaction\u2010studies\u2010cytochrome\u2010p450\u2010enzyme\u2010and\u2010transporter\u2010mediated\u2010drug\u2010interactions>."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1082"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.445"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2017.04.009"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2012.138"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2007.02998.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-014-1770-2"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.0c01144"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/psp4.12508"}],"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt.2089","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cpt.2089","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt.2089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:29:47Z","timestamp":1699363787000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt.2089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,13]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1002\/cpt.2089"],"URL":"https:\/\/doi.org\/10.1002\/cpt.2089","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,13]]},"assertion":[{"value":"2020-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}