{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T20:26:26Z","timestamp":1780604786682,"version":"3.54.1"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T00:00:00Z","timestamp":1606694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:p>Dual antiplatelet therapy (DAPT) is standard in acute coronary syndrome but confers a bleeding risk. To compare effects of clopidogrel single antiplatelet therapy (SAPT) with clopidogrel\u2010based DAPT on hemostatic system activation we conducted a randomized clinical trial in 44 volunteers (clopidogrel (d1: 600\u00a0mg, d2\u20106: 150\u00a0mg) \u00b1 aspirin (100\u00a0mg)). Multiple electrode aggregometry\u2010adenosine diphosphate (MEA\u2010ADP) and MEA\u2010arachidonic acid (MEA\u2010AA) triggered aggregometry, vasodilator\u2010stimulated phosphoprotein (VASP), beta thromboglobulin, p\u2010selectin, thromboxane B<jats:sub>2<\/jats:sub>, d\u2010Dimer, prothrombin fragment 1.2 (f1.2), and a phospholipid\u2010dependent clotting time were measured in venous blood. Changes are described by mean differences (\u0394mean (95% confidence interval (CI)) or geometric mean ratios (95% CI)). DAPT and SAPT comparably and significantly decreased MEA\u2010ADP at 2\u00a0hours (\u221260% vs. \u221263%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.35, \u0394mean \u22124.9, 95% CI \u221215.4 to 5.5). At 24\u00a0hours (\u221259% vs. \u221247%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04, \u0394mean \u221211.1, 95% CI \u221221.7 to \u22120.4]) and 8\u00a0days (\u221261% vs. \u221253%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04, \u0394mean \u221211.3, 95% CI \u221222.0 to \u22120.6). Both treatments significantly reduced VASP and MEA\u2010AA after 2\u00a0hours and 8\u00a0days. DAPT inhibited MEA\u2010AA significantly stronger at 2\u00a0hours (\u221277% vs. \u221230%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001, \u0394mean \u221239.6, 95% CI \u221254.2 to \u221225.0), at 24\u00a0hours (\u221280% vs. \u221227%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001, \u0394mean \u221247.8, 95% CI \u221262.3 to \u221233.3), and 8\u00a0days (\u221279% vs. \u221227%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001, \u0394mean \u221248.9, 95% CI \u221262.5 to \u221235.4). Neither treatment significantly influenced beta thromboglobulin or p\u2010selectin. DAPT abolished and SAPT reduced thromboxane B<jats:sub>2<\/jats:sub> after 24\u00a0hours and 8\u00a0days. The d\u2010Dimer was reduced by DAPT (0.94, 95% CI 0.89\u20131.00, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04) at 2\u00a0hours but not after 24\u00a0hours and 8\u00a0days. SAPT did not decrease d\u2010Dimer. Neither treatment affected f1.2. DAPT and SAPT comparably affect platelet and coagulation activation in venous blood.<\/jats:p>","DOI":"10.1002\/cpt.2106","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T19:45:21Z","timestamp":1604432721000},"page":"1546-1554","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Differential Effects of Clopidogrel With or Without Aspirin on Platelet Reactivity and Coagulation Activation: A Randomized Trial in Healthy Volunteers"],"prefix":"10.1111","volume":"109","author":[{"given":"Ludwig","family":"Traby","sequence":"first","affiliation":[{"name":"Department of Medicine I Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marietta","family":"Kollars","sequence":"additional","affiliation":[{"name":"Department of Medicine I Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Kaider","sequence":"additional","affiliation":[{"name":"Center for Medical Statistics Informatics and Intelligent Systems Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanta Maria","family":"Siller\u2010Matula","sequence":"additional","affiliation":[{"name":"Department of Medicine II Division of Cardiology Medical University of Vienna Vienna Austria"},{"name":"Department of Experimental and Clinical Pharmacology Centre for Preclinical Research and Technology (CEPT) Medical University of Warsaw Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oskar","family":"Steinbrecher","sequence":"additional","affiliation":[{"name":"Department of Medicine I Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Wolzt","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Alexander","family":"Kyrle","sequence":"additional","affiliation":[{"name":"Department of Medicine I Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Eichinger","sequence":"additional","affiliation":[{"name":"Department of Medicine I Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,30]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00804-4"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp492"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30677-8"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw334"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000441139.02102.80"},{"key":"e_1_2_10_6_1","article-title":"Antithrombotic therapy in patients with acute coronary syndrome complicated by cardiogenic shock or out\u2010of\u2010hospital cardiac arrest: a Joint Position Paper from the European Society of Cardiology (ESC) Working Group on Thrombosis, in association with the Acute Cardiovascular Care Association (ACCA) and European Association of Percutaneous Cardiovascular Interventions (EAPCI)","author":"Gorog D.A.","journal-title":"Eur. 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