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The primary aim was to conduct a real\u2010world pharmacokinetic (PK) evaluation to discover blood biomarkers of rapid clearance, identify exposure targets, and a secondary aim to translate PK modeling to the clinic. In a multicenter observational study, 671 peak and trough infliximab concentrations from 78 patients with CD were analyzed with a drug\u2010tolerant assay (Esoterix; LabCorp, Calabasas, CA). Individual area under the curve (AUC) estimates were generated as a measure of drug exposure over time. Population PK modeling (nonlinear mixed\u2010effect modeling) identified serum albumin, antibody to infliximab, erythrocyte sedimentation rate (ESR), and neutrophil CD64 as biomarkers for drug clearance. Week 14 and week 52 biochemical remitters (fecal calprotectin\u00a0&lt;\u00a0250\u00a0\u00b5g\/g) had higher infliximab exposure (AUC) throughout induction. The optimal infliximab AUC target during induction for week 14 biochemical remission was 79,348\u00a0\u00b5g*h\/mL (area under the receiver operating characteristic curve (AUROC) 0.77, [0.63\u20100.90], 85.7% sensitive, and 64.3% specific) with those exceeding the AUC target more likely to achieve a surgery\u2010free week 52 biochemical remission (OR 4.3, [1.2\u201314.6]). Pretreatment predictors for subtherapeutic week 14 AUC included neutrophil CD64\u00a0&gt;\u00a06 (OR 4.5, [1.4\u201317.8]), ESR\u00a0&gt;\u00a030\u00a0mm\/h (OR 3.8, [1.4\u201311]), age\u00a0&lt;\u00a010\u00a0years old (OR 4.2, [1.2\u201320]), and weight\u00a0&lt;\u00a030\u00a0kg (OR 6.6, [2.1\u201325]). We created a decision\u2010support PK dashboard with an iterative process and embedded the modeling program within the electronic health record. Model\u2010informed precision dosing guided by real\u2010world PKs is now available at the bedside in real\u2010time.<\/jats:p>","DOI":"10.1002\/cpt.2148","type":"journal-article","created":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T05:44:11Z","timestamp":1608788651000},"page":"1639-1647","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["Real\u2010World Infliximab Pharmacokinetic Study Informs an Electronic Health Record\u2010Embedded Dashboard to Guide Precision Dosing in Children with Crohn\u2019s Disease"],"prefix":"10.1111","volume":"109","author":[{"given":"Ye","family":"Xiong","sequence":"first","affiliation":[{"name":"Division of Clinical Pharmacology Cincinnati Children\u2019s Hospital Medical Center Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology 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