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The Clinical Pharmacogenetics Implementation Consortium (CPIC) has categorized over 35 gene\u2010drug pairs as \u201clevel A,\u201d for which there is sufficiently strong evidence to recommend that genetic information be used to guide drug prescribing. The opportunity to use genetic information to tailor pharmacotherapy among adult patients was determined by elucidating the exposure to CPIC level A drugs among 11 Implementing Genomics In Practice Network (IGNITE)\u2010affiliated health systems across the US. Inpatient and\/or outpatient electronic\u2010prescribing data were collected between January 1, 2011 and December 31, 2016 for patients\u00a0\u2265\u00a018\u00a0years of age who had at least one medical encounter that was eligible for drug prescribing in a calendar year. A median of ~\u00a07.2 million adult patients was available for assessment of drug prescribing per year. From 2011 to 2016, the annual estimated prevalence of exposure to at least one CPIC level A drug prescribed to unique patients ranged between 15,719 (95% confidence interval (CI): 15,658\u201315,781) in 2011 to 17,335 (CI: 17,283\u201317,386) in 2016 per 100,000 patients. The estimated annual exposure to at least 2 drugs was above 7,200 per 100,000 patients in most years of the study, reaching an apex of 7,660 (CI: 7,632\u20137,687) per 100,000 patients in 2014. An estimated 4,748 per 100,000 prescribing events were potentially eligible for a genotype\u2010guided intervention. Results from this study show that a significant portion of adults treated at medical institutions across the United States is exposed to medications for which genetic information, if available, should be used to guide prescribing.<\/jats:p>","DOI":"10.1002\/cpt.2161","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T06:22:11Z","timestamp":1610691731000},"page":"179-188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Opportunity for Genotype\u2010Guided Prescribing Among Adult Patients in 11 US Health Systems"],"prefix":"10.1111","volume":"110","author":[{"given":"J. Kevin","family":"Hicks","sequence":"first","affiliation":[{"name":"Department of Individualized Cancer Management H. 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