{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:40:41Z","timestamp":1787794841566,"version":"build-2784847793"},"reference-count":114,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T00:00:00Z","timestamp":1615420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R24 GM123930"],"award-info":[{"award-number":["R24 GM123930"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJY\u2010159710"],"award-info":[{"award-number":["PJY\u2010159710"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010523","name":"Centre for Addiction and Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010523","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009781","name":"Australian Centre for HIV and Hepatitis Virology Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2016\u201001153"],"award-info":[{"award-number":["2016\u201001153"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2016\u201001154"],"award-info":[{"award-number":["2016\u201001154"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2019\u201001837"],"award-info":[{"award-number":["2019\u201001837"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["668353"],"award-info":[{"award-number":["668353"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001646","name":"Robert Bosch Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>The Pharmacogene Variation Consortium (PharmVar) catalogs star (*) allele nomenclature for the polymorphic human <jats:italic>CYP2B6<\/jats:italic> gene. Genetic variation within the <jats:italic>CYP2B6<\/jats:italic> gene locus impacts the metabolism or bioactivation of clinically important drugs. Of particular importance are efficacy and safety concerns regarding: efavirenz, which is used for the treatment of HIV type\u20101 infection; methadone, a mainstay in the treatment of opioid use disorder and as an analgesic; ketamine, used as an antidepressant and analgesic; and bupropion, which is prescribed to treat depression and for smoking cessation. This GeneFocus provides a comprehensive overview and summary of <jats:italic>CYP2B6<\/jats:italic> and describes how haplotype information catalogued by PharmVar is utilized by the Pharmacogenomics Knowledgebase (PharmGKB) and the Clinical Pharmacogenetics Implementation Consortium (CPIC).<\/jats:p>","DOI":"10.1002\/cpt.2166","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T23:29:36Z","timestamp":1610753376000},"page":"82-97","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["PharmVar GeneFocus: <i>CYP2B6<\/i>"],"prefix":"10.1111","volume":"110","author":[{"given":"Zeruesenay","family":"Desta","sequence":"first","affiliation":[{"name":"Division of Clinical Pharmacology Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"El\u2010Boraie","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health and Departments of Pharmacology &amp; Toxicology, and Psychiatry University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data Science Stanford University Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew A","family":"Somogyi","sequence":"additional","affiliation":[{"name":"Discipline of Pharmacology Adelaide Medical School University of Adelaide Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker M.","family":"Lauschke","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Collet","family":"Dandara","sequence":"additional","affiliation":[{"name":"Division of Human Genetics Department of Pathology &amp; Institute of Infectious Disease and Molecular Medicine Faculty of Health Sciences University of Cape Town Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Klein","sequence":"additional","affiliation":[{"name":"Dr. Margarete Fischer\u2010Bosch\u2010Institute of Clinical Pharmacology Stuttgart Germany"},{"name":"University of Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil A.","family":"Miller","sequence":"additional","affiliation":[{"name":"Genomic Medicine Center Children\u2019s Mercy Kansas City Missouri USA"},{"name":"School of Medicine University of Missouri\u2010Kansas City Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teri E.","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data Science Stanford University Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel F.","family":"Tyndale","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health and Departments of Pharmacology &amp; Toxicology, and Psychiatry University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Whirl\u2010Carrillo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data Science Stanford University Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gaedigk","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Toxicology &amp; Therapeutic Innovation Children\u2019s Mercy Kansas City Missouri USA"},{"name":"School of Medicine University of Missouri\u2010Kansas City Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,11]]},"reference":[{"key":"e_1_2_28_1_1","first-page":"224","article-title":"Induction of the unspecific microsomal hydroxylase in the human liver","volume":"1","author":"Remmer H.","year":"1973","journal-title":"Drug Metab. Dispos."},{"key":"e_1_2_28_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/16.13.5783"},{"key":"e_1_2_28_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1988.tb01088.x"},{"key":"e_1_2_28_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-199602000-00002"},{"key":"e_1_2_28_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00173169"},{"key":"e_1_2_28_6_1","unstructured":"Genotype\u2010Tissue Expression (GTEx) Project<https:\/\/gtexportal.org\/home\/>."},{"key":"e_1_2_28_7_1","first-page":"414","article-title":"Interindividual variations in human liver cytochrome P\u2010450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians","volume":"270","author":"Shimada T.","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_28_8_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.168.67"},{"key":"e_1_2_28_9_1","doi-asserted-by":"publisher","DOI":"10.2217\/14622416.8.7.743"},{"key":"e_1_2_28_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2013.00024"},{"key":"e_1_2_28_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200107000-00004"},{"key":"e_1_2_28_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.4524"},{"key":"e_1_2_28_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200310000-00005"},{"key":"e_1_2_28_14_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.049601"},{"key":"e_1_2_28_15_1","first-page":"2391","article-title":"Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study","volume":"18","author":"Haas D.W.","year":"2004","journal-title":"AIDS"},{"key":"e_1_2_28_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.05.116"},{"key":"e_1_2_28_17_1","doi-asserted-by":"publisher","DOI":"10.2217\/14622416.8.6.547"},{"key":"e_1_2_28_18_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.133306"},{"key":"e_1_2_28_19_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.48.113006.094753"},{"key":"e_1_2_28_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e32835a450b"},{"key":"e_1_2_28_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2016.11.010"},{"key":"e_1_2_28_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.00007"},{"key":"e_1_2_28_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200002000-00012"},{"key":"e_1_2_28_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.910"},{"key":"e_1_2_28_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1654"},{"key":"e_1_2_28_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-199706000-00001"},{"key":"e_1_2_28_27_1","first-page":"5629","article-title":"Differential activation of cyclophosphamide and ifosphamide by cytochromes P\u2010450 2B and 3A in human liver microsomes","volume":"53","author":"Chang T.K.","year":"1993","journal-title":"Cancer Res."},{"key":"e_1_2_28_28_1","first-page":"948","article-title":"Catalytic role of cytochrome P4502B6 in the N\u2010demethylation of S\u2010mephenytoin","volume":"24","author":"Heyn H.","year":"1996","journal-title":"Drug Metab. Dispos."},{"key":"e_1_2_28_29_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.30.5.525"},{"key":"e_1_2_28_30_1","first-page":"1222","article-title":"Validation of bupropion hydroxylation as a selective marker of human cytochrome P450 2B6 catalytic activity","volume":"28","author":"Faucette S.R.","year":"2000","journal-title":"Drug Metab. Dispos."},{"key":"e_1_2_28_31_1","first-page":"1176","article-title":"CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants","volume":"28","author":"Hesse L.M.","year":"2000","journal-title":"Drug Metab. Dispos."},{"key":"e_1_2_28_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz329"},{"key":"e_1_2_28_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41397-019-0112-2"},{"key":"e_1_2_28_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2011.34"},{"key":"e_1_2_28_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr272"},{"key":"e_1_2_28_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1477"},{"key":"e_1_2_28_37_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920008785821710"},{"key":"e_1_2_28_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/01213011-200501000-00001"},{"key":"e_1_2_28_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000867"},{"key":"e_1_2_28_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e32835d9ab0"},{"key":"e_1_2_28_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdd.665"},{"key":"e_1_2_28_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12614"},{"key":"e_1_2_28_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2015.03.022"},{"key":"e_1_2_28_44_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.110.065185"},{"key":"e_1_2_28_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2011.129"},{"key":"e_1_2_28_46_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.110.035246"},{"key":"e_1_2_28_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.12671"},{"key":"e_1_2_28_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2015.37"},{"key":"e_1_2_28_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.667"},{"key":"e_1_2_28_50_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01000-16"},{"key":"e_1_2_28_51_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.056127"},{"key":"e_1_2_28_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2005.02.010"},{"key":"e_1_2_28_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-008-0594-3"},{"key":"e_1_2_28_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21020211"},{"key":"e_1_2_28_55_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.114.060962"},{"key":"e_1_2_28_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1496"},{"key":"e_1_2_28_57_1","unstructured":"Drug Interactions Flockhart Table\u2122<https:\/\/drug\u2010interactions.medicine.iu.edu\/Main\u2010Table.aspx>."},{"key":"e_1_2_28_58_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.115.067546"},{"key":"e_1_2_28_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2009.03.029"},{"key":"e_1_2_28_60_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e318040b29e"},{"key":"e_1_2_28_61_1","first-page":"1","article-title":"Altered methadone pharmacokinetics in methadone\u2010maintained pregnant women","volume":"233","author":"Pond S.M.","year":"1985","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_28_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.43"},{"key":"e_1_2_28_63_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.116.071530"},{"key":"e_1_2_28_64_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.112.047118"},{"key":"e_1_2_28_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13266"},{"key":"e_1_2_28_66_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.054866"},{"key":"e_1_2_28_67_1","doi-asserted-by":"publisher","DOI":"10.3109\/00498251003713958"},{"key":"e_1_2_28_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12070"},{"key":"e_1_2_28_69_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.112.048108"},{"key":"e_1_2_28_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2012.96"},{"key":"e_1_2_28_71_1","unstructured":"PharmGKB CYP2B6 gene page<https:\/\/www.pharmgkb.org\/gene\/PA123>."},{"key":"e_1_2_28_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1651"},{"key":"e_1_2_28_73_1","unstructured":"CPIC Guidelines<https:\/\/cpicpgx.org\/guidelines\/>."},{"key":"e_1_2_28_74_1","unstructured":"CPIC Gene\/drug pairs<https:\/\/cpicpgx.org\/genes\u2010drugs\/>."},{"key":"e_1_2_28_75_1","unstructured":"PharmGKB Gene\u2010specific Information Tables for CYP2B6<https:\/\/www.pharmgkb.org\/page\/cyp2b6RefMaterials>."},{"key":"e_1_2_28_76_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.033233"},{"key":"e_1_2_28_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100072"},{"key":"e_1_2_28_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2018.09.010"},{"key":"e_1_2_28_79_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e32833bba0e"},{"key":"e_1_2_28_80_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.111.039586"},{"key":"e_1_2_28_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1973"},{"key":"e_1_2_28_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.280"},{"key":"e_1_2_28_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2018.01.011"},{"key":"e_1_2_28_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2019.04.003"},{"key":"e_1_2_28_85_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.41.1.123"},{"key":"e_1_2_28_86_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.104.008086"},{"key":"e_1_2_28_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.892"},{"key":"e_1_2_28_88_1","unstructured":"PharmVar CYP2B6 gene page<https:\/\/www.pharmvar.org\/gene\/CYP2B6>."},{"key":"e_1_2_28_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1322"},{"key":"e_1_2_28_90_1","doi-asserted-by":"publisher","DOI":"10.3109\/03602532.2014.982864"},{"key":"e_1_2_28_91_1","doi-asserted-by":"publisher","DOI":"10.1097\/01213011-200512000-00004"},{"key":"e_1_2_28_92_1","unstructured":"PharmVar Allele Designation and Evidence Level document<www.pharmvar.org\/documents\/Allele_Designation_and_Evidence_Level_Criteria_V2.1.pdf>."},{"key":"e_1_2_28_93_1","unstructured":"PharmVar CYP2B6 Gene Expert Panel<https:\/\/www.pharmvar.org\/expert\u2010panels>."},{"key":"e_1_2_28_94_1","unstructured":"PharmVar Legacy P450 Nomenclature site content<https:\/\/www.pharmvar.org\/htdocs\/archive\/index_original.htm>; previoulsy at cypalleles.ki\/se."},{"key":"e_1_2_28_95_1","unstructured":"Locus Reference Genomic (LRG) Records<https:\/\/www.lrg\u2010sequence.org\/>."},{"key":"e_1_2_28_96_1","unstructured":"PharmVar Standards<https:\/\/www.pharmvar.org\/genes>."},{"key":"e_1_2_28_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1643"},{"key":"e_1_2_28_98_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2015.0039"},{"key":"e_1_2_28_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.156"},{"key":"e_1_2_28_100_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.119.090407"},{"key":"e_1_2_28_101_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.068973"},{"key":"e_1_2_28_102_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.111.040352"},{"key":"e_1_2_28_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1275"},{"key":"e_1_2_28_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2015.08.005"},{"key":"e_1_2_28_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/npjgenmed.2015.7"},{"key":"e_1_2_28_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-018-0054-0"},{"key":"e_1_2_28_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03273-1"},{"key":"e_1_2_28_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.10.005"},{"key":"e_1_2_28_109_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2015.0048"},{"key":"e_1_2_28_110_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv402"},{"key":"e_1_2_28_111_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00486"},{"key":"e_1_2_28_112_1","unstructured":"PharmGKB CYP2B6 Drug Label Annotations<https:\/\/www.pharmgkb.org\/gene\/PA123\/labelAnnotation>."},{"key":"e_1_2_28_113_1","unstructured":"FDA Pharmacogenomic Biomarkers in Drug Labeling<https:\/\/www.fda.gov\/drugs\/science\u2010research\u2010drugs\/table\u2010pharmacogenomic\u2010biomarkers\u2010drug\u2010labeling>."},{"key":"e_1_2_28_114_1","unstructured":"NCBI.Reference Sequences database<https:\/\/www.ncbi.nlm.nih.gov\/refseq\/>."}],"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt.2166","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cpt.2166","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt.2166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T07:19:01Z","timestamp":1709709541000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt.2166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,11]]},"references-count":114,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1002\/cpt.2166"],"URL":"https:\/\/doi.org\/10.1002\/cpt.2166","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,11]]},"assertion":[{"value":"2020-10-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}