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Beta\u2010lactams represent the most widely prescribed antibiotic class, yet most were licensed prior to legislation changes mandating their study in children. As a result, significant heterogeneity persists in the pediatric doses used globally, along with quality of evidence used to inform dosing. This review summarizes dosing recommendations from the major pediatric reference sources and tries to answer the questions: Does beta\u2010lactam dose heterogeneity matter? Does it impact pharmacodynamic target attainment? For three important severe clinical infections\u2014pneumonia, sepsis, and meningitis\u2014pharmacokinetic models were identified for common for beta\u2010lactam antibiotics. Real\u2010world demographics were derived from three multicenter point prevalence surveys. Simulation results were compared with minimum inhibitory concentration distributions to inform appropriateness of recommended doses in targeted and empiric treatment. 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