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Pharmacokinetic\/pharmacodynamic (PK\/PD) models can be used to optimize dose selection as they define the drug exposure\u2010response relationship. Additionally, these models are able to identify patient characteristics that cause alterations in the expected PK\/PD profiles and through simulations can recommend changes to dosing which compensate for the differences. In this review, we examine how PK\/PD models have been applied to optimize antimalarial dosing recommendations for young children, including those who are malnourished, pregnant women, and individuals receiving concomitant therapies such as those for HIV treatment. The malaria field has had great success in utilizing PK\/PD models as a foundation to update treatment guidelines and propose the next generation of dosing regimens to investigate in clinical trials. We propose how the malaria field can continue to use modeling to improve therapies by further integrating PK data into clinical studies and including data on drug resistance and host immunity in PK\/PD models. 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