{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T05:56:30Z","timestamp":1720763790916},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T00:00:00Z","timestamp":1628553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:p>Our previous study showed that parenteral anticoagulation therapy (PACT) in the context of aggressive antiplatelet therapy failed to improve clinical outcomes in patients undergoing percutaneous coronary intervention for non\u2013ST\u2010segment elevation acute coronary syndrome (NSTE\u2010ACS). However, the role of PACT in patients managed medically remains unknown. This observational cohort study enrolled patients with NSTE\u2010ACS receiving medical therapy from November 2014 to June 2017 in the Improving Care for Cardiovascular Disease in China\u2010Acute Coronary Syndrome project. Eligible patients were included in the PACT group and non\u2010PACT group. The primary outcomes were in\u2010hospital all\u2010cause mortality and major bleeding. The secondary outcome included minor bleeding. Among 23,726 patients, 8,845 eligible patients who received medical therapy were enrolled. After adjusting the potential confounders, PACT was not associated with a lower risk of in\u2010hospital all\u2010cause mortality (adjusted odds ratio (OR), 1.25; 95% confidence interval (CI), 0.92\u20131.71; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.151). Additionally, PACT did not increase the incidence of major bleeding or minor bleeding (major bleeding: adjusted OR, 1.04; 95% CI, 0.80\u20131.35; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.763; minor bleeding: adjusted OR, 1.27; 95% CI, 0.91\u20131.75; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.156). The propensity score analysis confirmed the primary analyses. In patients with NSTE\u2010ACS receiving antiplatelet therapy, PACT was not associated with a lower risk of in\u2010hospital all\u2010cause mortality or a higher bleeding risk in patients with NSTE\u2010ACS receiving non\u2010invasive therapies and concurrent antiplatelet strategies. Randomized clinical trials are warranted to reevaluate the safety and efficacy of PACT in all patients with NSTE\u2010ACS who receive noninvasive therapies and current antithrombotic strategies.<\/jats:p>","DOI":"10.1002\/cpt.2370","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T15:54:38Z","timestamp":1626710078000},"page":"1119-1126","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of Parenteral Anticoagulation Therapy With Outcomes in Non\u2013ST\u2010Segment Elevation Acute Coronary Syndrome Patients Without Invasive Therapy: Findings from the Improving Care for Cardiovascular Disease in China (CCC) project"],"prefix":"10.1111","volume":"110","author":[{"given":"Yuan\u2010Hui","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Cardiology Guangdong Cardiovascular Institute Guangdong Provincial Key Laboratory of Coronary Heart Disease 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